LIGHT   Click here for help

GtoPdb Ligand ID: 5070

Synonyms: Herpesvirus entry mediator-ligand | TR2
Immunopharmacology Ligand
Comment: LIGHT is a tumour necrosis factor superfamily protein that regulates T-cell-based inflammatory reactions, especially in mucosal membranes [1-2]. It exists as a membrane-anchored protein and as a soluble form in the serum. LIGHT's biological activity is mediated via binding to TNF superfamily receptors: lymphotoxin β receptor (LTβR; TNFRSF3), herpes virus entry mediator (HVEM; TNFRSF14), and decoy receptor 3 (DcR3; TNFRSF6B).
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands)Tumor necrosis factor superfamily ligands
Synonyms Click here for help
Herpesvirus entry mediator-ligand | TR2
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF14 TNF superfamily member 14 Human prepro-tumor necrosis factor ligand superfamily member 14 CD258, HVEM-L, LIGHT, LTg, tumor necrosis factor (ligand) superfamily, member 14, tumor necrosis factor superfamily member 14
Database Links Click here for help
Ensembl Gene ENSG00000125735 (Hs)
GtoPdb PubChem SID 178101763
Human Protein Atlas ENSG00000125735 (Hs)
UniProtKB O43557 (Hs)
Wikipedia TNFSF14