LIGHT   Click here for help

GtoPdb Ligand ID: 5070

Synonyms: Herpesvirus entry mediator-ligand | TR2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: LIGHT is a tumour necrosis factor superfamily protein that regulates T-cell-based inflammatory reactions, especially in mucosal membranes [1-2]. It exists as a membrane-anchored protein and as a soluble form in the serum. LIGHT's biological activity is mediated via binding to TNF superfamily receptors: lymphotoxin β receptor (LTβR; TNFRSF3), herpes virus entry mediator (HVEM; TNFRSF14), and decoy receptor 3 (DcR3; TNFRSF6B).
Species: Human
Natural/Endogenous Targets
Target
decoy receptor 3
herpes virus entry mediator
lymphotoxin β receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
lymphotoxin β receptor Ligand is endogenous in the given species Hs None - - - -
⤷
herpes virus entry mediator Ligand is endogenous in the given species Hs None - - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
quisovalimab Peptide Hs Antibody Binding - - - 3
⤷ [3]
Targets where the ligand is described in the comment field
Target Comment
decoy receptor 3 Decoy receptor for LIGHT (TNFSF14, O43557), TL1A (TNFSF15, O95150) and Fas ligand (FASLG, P48023).