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|Compound class||Endogenous peptide in human, mouse or rat|
|Ligand families/groups||Vascular endothelial growth factor (VEGF) family ligands|
|vascular endothelial growth factor A | vascular permeability factor (VPF) | VEGF-A|
|The active peptide is anti-parallel homodimer linked by disulphide bonds. VEGFA exists as four isoforms of 121, 165, 189 and 206 amino acids. The shortest variant contains the full VEGFR2 binding site but lacks domains that are involved in interactions with extracellular-matrix and co-receptors which are present in the longer isoforms [13-14].
A recombinant single-chain derivative of VEGFA121 (scVEGF) can be used experimentally as a fully functional peptide that binds and activates VEGFR2 in the same manner as endogenous VEGFA . scVEGF can be labelled with a single fluorophore at its N-terminal, for use as a molecular probe .
|DrugBank Target||P15692 (Hs)|
|Ensembl Gene||ENSG00000112715 (Hs)|
|GtoPdb PubChem SID||178101778|
|Human Protein Atlas||ENSG00000112715 (Hs)|