VEGFA

Ligand id: 5085

Name: VEGFA

Species: Human

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
Target
fms related tyrosine kinase 1
kinase insert domain receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Agonist Agonist 8.0 – 9.6 pKd - 10
pKd 9.6 (Kd 2.3x10-10 M) [10]
Description: Dissociation constant for scVEGF-binding to dimeric VEGFR2.
pKd 8.0 (Kd 1x10-8 M) [10]
Description: Dissociation constant for scVEGF-binding to monomeric VEGFR2.
fms related tyrosine kinase 1 Hs None - - - -
kinase insert domain receptor Hs None - - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
abicipar pegol Hs Inhibitor Inhibition 11.7 pKd - 6
pKd 11.7 (Kd 2x10-12 M) [6]
vanucizumab Hs Antibody Binding >10.0 pKd - 4
pKd >10.0 (Kd <1x10-10 M) [4]
ranibizumab Hs Antibody Binding 9.8 pKd - 2
pKd 9.8 (Kd 1.5x10-10 M) [2]
brolucizumab Hs Antibody Binding 8.8 pKd - 5
pKd 8.8 (Kd 1.59x10-9 M) [5]
bevacizumab Hs Antibody Binding 8.0 – 8.3 pIC50 - 2
pIC50 8.0 – 8.3 (IC50 1x10-8 – 5x10-9 M) [2]
aflibercept Hs Antagonist Inhibition - - - 7-8,12
[7-8,12]
pegaptanib Hs Antagonist Inhibition - - - 9,11
[9,11]
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