guanfacine   Click here for help

GtoPdb Ligand ID: 522

Synonyms: Estulic® | Intuniv® | Tenex®
Approved drug
guanfacine is an approved drug (FDA (1986), EMA (2015))
Compound class: Synthetic organic
Comment: Guanfacine is a centrally acting sympatholytic drug acting via activation of α2-adrenoceptors.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 81.47
Molecular weight 245.01
XLogP 2.04
No. Lipinski's rules broken 0
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Canonical SMILES O=C(Cc1c(Cl)cccc1Cl)N=C(N)N
Isomeric SMILES O=C(Cc1c(Cl)cccc1Cl)N=C(N)N
InChI InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1986), EMA (2015))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
3999 guanfacine
Synonyms Click here for help
Estulic® | Intuniv® | Tenex®
Database Links Click here for help
Specialist databases
GPCRdb Ligand guanfacine
Other databases
BindingDB Ligand 81984
CAS Registry No. 29110-47-2
DrugBank Ligand DB01018
DrugCentral Ligand 1343
GtoPdb PubChem SID 135650327
PubChem CID 3519
Search Google for chemical match using the InChIKey INJOMKTZOLKMBF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone INJOMKTZOLKMBF
Search PubMed clinical trials guanfacine
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UniChem Compound Search for chemical match using the InChIKey INJOMKTZOLKMBF-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey INJOMKTZOLKMBF-UHFFFAOYSA-N
Wikipedia Guanfacine