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Synonyms: A-64077 | ZYFLO®
zileuton is an approved drug (FDA (1996))
Compound class: Synthetic organic
Comment: Zileuton is an orally active 5-LOX inhibitor.
The approved drug is a racemic mixture of R(+) and S(-) enantiomers (PubChem CID 10681296 and CID 10220327 respectively), which are both pharmacologically active. The structure shown here does not specify stereochemistry and represents the mixture.
The hepatotoxicity of zileuton is suggested to be due to the N-hydroxyurea group .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: zileuton
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (1996))|
|International Nonproprietary Names|
|A-64077 | ZYFLO®|
|CAS Registry No.||111406-87-2|
|GtoPdb PubChem SID||178101979|
|Search Google for chemical match using the InChIKey||MWLSOWXNZPKENC-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||MWLSOWXNZPKENC|
|Search PubMed clinical trials||zileuton|
|Search PubMed titles||zileuton|
|Search PubMed titles/abstracts||zileuton|
|Search UniChem for chemical match using the InChIKey||MWLSOWXNZPKENC-UHFFFAOYSA-N|
|Search UniChem for chemicals with the same backbone||MWLSOWXNZPKENC|
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Cat. No. 3308