ximelagatran   Click here for help

GtoPdb Ligand ID: 6381

Synonyms: H 376-95 | H 376/95
Approved drug
ximelagatran is an approved drug
Compound class: Synthetic organic
Comment: Ximelagatran is a prodrug of the active prothrombin inhibitor melagatran. Applications for approval of ximelagatran were withdrawn in 2006.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 13
Topological polar surface area 146.35
Molecular weight 473.26
XLogP 2.39
No. Lipinski's rules broken 1
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Canonical SMILES CCOC(=O)CNC(C(=O)N1CCC1C(=O)NCc1ccc(cc1)C(=NO)N)C1CCCCC1
Isomeric SMILES CCOC(=O)CN[C@@H](C(=O)N1CC[C@H]1C(=O)NCc1ccc(cc1)/C(=N/O)/N)C1CCCCC1
InChI InChI=1S/C24H35N5O5/c1-2-34-20(30)15-26-21(17-6-4-3-5-7-17)24(32)29-13-12-19(29)23(31)27-14-16-8-10-18(11-9-16)22(25)28-33/h8-11,17,19,21,26,33H,2-7,12-15H2,1H3,(H2,25,28)(H,27,31)/t19-,21+/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
Withdrawn drug? Yes
Is prodrug? Yes
Active form melagatran
IUPAC Name Click here for help
ethyl 2-[[(1R)-1-cyclohexyl-2-[(2S)-2-[[4-(N'-hydroxycarbamimidoyl)phenyl]methylcarbamoyl]azetidin-1-yl]-2-oxoethyl]amino]acetate
International Nonproprietary Names Click here for help
INN number INN
8037 ximelagatran
Synonyms Click here for help
H 376-95 | H 376/95
Database Links Click here for help
CAS Registry No. 192939-46-1 (source: PubChem)
ChEMBL Ligand CHEMBL522038
DrugBank Ligand DB04898
DrugCentral Ligand 2852, 2852
GtoPdb PubChem SID 178102999
PubChem CID 9574101
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UniChem Compound Search for chemical match using the InChIKey ZXIBCJHYVWYIKI-PZJWPPBQSA-N
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Wikipedia Ximelagatran