certolizumab pegol   Click here for help

GtoPdb Ligand ID: 6774

Synonyms: CDP870 | Cimzia® | PHA 738144
Approved drug Immunopharmacology Ligand
certolizumab pegol is an approved drug (FDA (2008), EMA (2009))
Compound class: Antibody
Comment: This therapeutic is a TNFα neutralising agent. Structurally it is a Fab' fragment of a TNFα-binding monoclonal antibody, which has polyethylene glycol (PEG) conjugated to a free cysteine residue in its hinge region (Cys227 of the heavy chain). Removing the Fc portion minimizes complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC), two reactions known to cause unwanted side-effects in mAb therapies. PEGylation is used to increase the drug's half life, as Fab' fragments are normally rapidly degraded in vivo.
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Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA (2008), EMA (2009))
International Nonproprietary Names Click here for help
INN number INN
8448 certolizumab pegol
Synonyms Click here for help
CDP870 | Cimzia® | PHA 738144
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 242
Other databases
GtoPdb PubChem SID 178103380
PubChem SID 178103380
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Wikipedia Certolizumab_pegol