Synonyms: Fab-12 variant Y0317 | Lucentis® | muMAb VEGF A.4.6.1 | rhuFab V2
ranibizumab is an approved drug (FDA (2006), EMA (2007))
Compound class:
Antibody
Comment: Ranibizumab is a Fab fragment of a monoclonal antibody designed to target vascular endothelial growth factor A (VEGFA).
Annotated peptide sequences for this antibody derivative are available from its IMGT/mAb-DB record. Peptide sequence analysis reveals that ranibizumab sequences are claimed in patent WO1998045331 (clone Y0317) [2], with an expected affinity similar to clone Y0313-1. It is the Fab fragment of bevacizumab. Biosimilars:
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Classification ![]() |
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Compound class | Antibody |
Approved drug? | Yes (FDA (2006), EMA (2007)) |
Approved drug? | Yes. FDA (2006) | EMA (2007) |
International Nonproprietary Names ![]() |
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INN number | INN |
8313 | ranibizumab |
Synonyms ![]() |
Fab-12 variant Y0317 | Lucentis® | muMAb VEGF A.4.6.1 | rhuFab V2 |
Database Links ![]() |
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Specialist databases | |
IMGT/mAb-DB | 84 |
Reactome Drug
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R-ALL-9679464 |
Reactome Reaction
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R-HSA-9679477 |
Other databases | |
GtoPdb PubChem SID | 178103385 |
PubChem SID | 178103385 |
Search PubMed clinical trials | ranibizumab |
Search PubMed titles | ranibizumab |
Search PubMed titles/abstracts | ranibizumab |
Wikipedia | Ranibizumab |