ranibizumab   Click here for help

GtoPdb Ligand ID: 6779

Synonyms: Fab-12 variant Y0317 | Lucentis® | muMAb VEGF A.4.6.1 | rhuFab V2
Approved drug
ranibizumab is an approved drug (FDA (2006), EMA (2007))
Compound class: Antibody
Comment: Ranibizumab is a Fab fragment of a monoclonal antibody designed to target vascular endothelial growth factor A (VEGFA).
Annotated peptide sequences for this antibody derivative are available from its IMGT/mAb-DB record.
Peptide sequence analysis reveals that ranibizumab sequences are claimed in patent WO1998045331 (clone Y0317) [2], with an expected affinity similar to clone Y0313-1. It is the Fab fragment of bevacizumab.

Biosimilars:
Name(s)Trade nameCompanyClinical PhaseIndications
Razumab®Intas PharmaceuticalsApproved (India 2015)As per reference agent
SB11; ranibizumab-nunaByooviz®Samsung BioepisApproved (EMA & FDA 2021)As per reference agent
Susvimo®Genentech/RocheApproved (FDA 2021)wet AMD
FYB201; ranibizumab-eqrnCimerli®Coherus BioSciencesApproved (FDA 2022)As per reference agent
Ranivisio®Midas PharmaApproved (EMA 2022)wet AMD
Ximluci®STADA ArzneimittelApproved (EMA 2022)As per reference agent
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VEGFA Primary target of this compound Hs Antibody Binding 9.8 pKd - 1
⤷ pKd 9.8 (Kd 1.5x10-10 M) [1]