dicumarol   Click here for help

GtoPdb Ligand ID: 6808

Synonyms: bishydroxycoumarin | Melitoxin®
Approved drug
dicumarol is an approved drug (FDA (1944))
Compound class: Synthetic organic
Comment: Vitamin K epoxide reductase complex subunit 1 isoform 1 inhibitor
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 100.88
Molecular weight 336.06
XLogP 4.22
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=c1oc2ccccc2c(c1Cc1c(=O)oc2c(c1O)cccc2)O
Isomeric SMILES O=c1oc2ccccc2c(c1Cc1c(=O)oc2c(c1O)cccc2)O
InChI InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2
InChI Key DOBMPNYZJYQDGZ-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1944))
Withdrawn drug? Yes
IUPAC Name Click here for help
4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one
Synonyms Click here for help
bishydroxycoumarin | Melitoxin®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9035047
Reactome Reaction Reactome logo R-HSA-9026967
Other databases
CAS Registry No. 66-76-2
ChEMBL Ligand CHEMBL1466
DrugBank Ligand DB00266
DrugCentral Ligand 867
GtoPdb PubChem SID 178103414
PubChem CID 54676038
Search Google for chemical match using the InChIKey DOBMPNYZJYQDGZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DOBMPNYZJYQDGZ
UniChem Compound Search for chemical match using the InChIKey DOBMPNYZJYQDGZ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey DOBMPNYZJYQDGZ-UHFFFAOYSA-N
Wikipedia Dicumarol