lesinurad   Click here for help

GtoPdb Ligand ID: 7673

Synonyms: RDEA-594 | RDEA594 | Zurampic®
Approved drug PDB Ligand
lesinurad is an approved drug (FDA (2015), EMA (2016))
Compound class: Synthetic organic
Comment: Lesinurad is an orally available inhibitor of URAT1, the renal transporter that regulates uric acid excretion from the body [1-2].
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 92.79
Molecular weight 403
XLogP 5.93
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES OC(=O)CSc1nnc(n1c1ccc(c2c1cccc2)C1CC1)Br
Isomeric SMILES OC(=O)CSc1nnc(n1c1ccc(c2c1cccc2)C1CC1)Br
InChI InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
InChI Key FGQFOYHRJSUHMR-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2015), EMA (2016))
IUPAC Name Click here for help
2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
International Nonproprietary Names Click here for help
INN number INN
9345 lesinurad
Synonyms Click here for help
RDEA-594 | RDEA594 | Zurampic®
Database Links Click here for help
CAS Registry No. 878672-00-5 (source: SciFinder)
ChEMBL Ligand CHEMBL2105720
DrugCentral Ligand 5075
GtoPdb PubChem SID 223366008
PubChem CID 53465279
RCSB PDB Ligand A1AIL
Search Google for chemical match using the InChIKey FGQFOYHRJSUHMR-UHFFFAOYSA-N
Search Google for chemicals with the same backbone FGQFOYHRJSUHMR
Search PubMed clinical trials lesinurad
Search PubMed titles lesinurad
Search PubMed titles/abstracts lesinurad
UniChem Compound Search for chemical match using the InChIKey FGQFOYHRJSUHMR-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey FGQFOYHRJSUHMR-UHFFFAOYSA-N