lanicemine   Click here for help

GtoPdb Ligand ID: 7681

Synonyms: AR-R15896AR | ARL 15896 | AZD-6765 | AZD6765
Compound class: Synthetic organic
Comment: Lanicemine (AZD 6765) was originally developed as a neuroprotective agent, but was repurposed as an antidepressant with potential for the management of severe and treatment-resistant depression [3]. However, the compound failed to meet study endpoints, so development was halted. The compound is discussed in the AZ 2014 review paper [1].
The structure represented here shows stereochemistry identical to the INN record wheras PubChem CID 3038485 represents the non-chiral molecule.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 38.91
Molecular weight 198.12
XLogP 1.95
No. Lipinski's rules broken 0
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Canonical SMILES NC(c1ccccc1)Cc1ccccn1
Isomeric SMILES N[C@H](c1ccccc1)Cc1ccccn1
InChI InChI=1S/C13H14N2/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12/h1-9,13H,10,14H2/t13-/m0/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
7943 lanicemine
Synonyms Click here for help
AR-R15896AR | ARL 15896 | AZD-6765 | AZD6765
Database Links Click here for help
CAS Registry No. 153322-05-5 (source: SciFinder)
ChEMBL Ligand CHEMBL467084
GtoPdb PubChem SID 223366016
PubChem CID 9794203
Search Google for chemical match using the InChIKey FWUQWDCOOWEXRY-ZDUSSCGKSA-N
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Search PubMed clinical trials lanicemine
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UniChem Compound Search for chemical match using the InChIKey FWUQWDCOOWEXRY-ZDUSSCGKSA-N
UniChem Connectivity Search for chemical match using the InChIKey FWUQWDCOOWEXRY-ZDUSSCGKSA-N
Wikipedia Lanicemine