GtoPdb Ligand ID: 7989

Synonyms: CNTO 136 | CNTO-136 | Plivensia (proposed trade name)
Compound class: Antibody
Comment: Sirukumab is a monoclonal antibody directed against interleukin 6 (IL-6), in development as an immunomodulator for the treatment of rheumatoid arthritis (RA). It is also being tested as an immunopsychiatry therapy to treat depression.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Peptide sequence BLAST search using the heavy chain variable region of sirukumab provides100% match to a sequence claimed in patent US7560112 [1], and to the antibody with designation AME-19a.
Compound class Antibody
International Nonproprietary Names
INN number INN
9431 sirukumab
CNTO 136 | CNTO-136 | Plivensia (proposed trade name)
Database Links
Specialist databases
IMGT/mAb-DB 384
Other databases
GtoPdb PubChem SID 249565670
Search PubMed clinical trials sirukumab
Search PubMed titles sirukumab
Search PubMed titles/abstracts sirukumab
Wikipedia Sirukumab