MB-3   Click here for help

GtoPdb Ligand ID: 8393

Synonyms: α-methylene-γ-butyrolactone 3
Compound class: Synthetic organic
Comment: MB-3 is reported as a cell-permeable small-molecule inhibitor of the histone acetyltransferase enzyme, general control nonderepressible 5 (GCN5, gene symbol KAT2B) [1]. In vitro, MB-3 has been shown to inhibit GCN5-driven acetylation of the chimeric oncoprotein E2A-PBX1 [4]. E2A-PBX1 is a non-histone target of GCN5 [5].
A 2017 article by Dahlin et al. suggests that the thiol-reactivity of MB-3 brings in to question its activity as a selective HAT inhibitor [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 80.67
Molecular weight 186.05
XLogP 0.49
No. Lipinski's rules broken 0
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Canonical SMILES CCCC1OC(=O)C(=O)C1C(=O)O
Isomeric SMILES CCC[C@@H]1OC(=O)C(=O)[C@H]1C(=O)O
InChI InChI=1S/C8H10O5/c1-2-3-4-5(7(10)11)6(9)8(12)13-4/h4-5H,2-3H2,1H3,(H,10,11)/t4-,5-/m0/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(2S,3S)-4,5-dioxo-2-propyloxolane-3-carboxylic acid
Synonyms Click here for help
α-methylene-γ-butyrolactone 3
Database Links Click here for help
GtoPdb PubChem SID 252166604
PubChem CID 91827357
Search Google for chemical match using the InChIKey AKWJFOMNTDKSRR-WHFBIAKZSA-N
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