codrituzumab   Click here for help

GtoPdb Ligand ID: 8406

Synonyms: GC33 | RG-7686 | RG7686 | RO-5137382 | RO5137382
Compound class: Antibody
Comment: Codrituzumab is the first-in-class, recombinant, humanized monoclonal antibody which binds to glypican-3 (GPC3). GPC3 is an oncofetal protein highly expressed in hepatocellular carcinoma (HCC) cells [1,4-5]. The anti-GPC3 antibody has been modified to carry fewer fucose sugar chains with the aim of increasing its cytotoxic activity, and therefore improving its inhibitory effect on cell growth, providing an enhanced anticancer agent.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. Peptide sequence match identifies US7867734 as the covering patent [3].
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
9759 codrituzumab
Synonyms Click here for help
GC33 | RG-7686 | RG7686 | RO-5137382 | RO5137382
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 466
Other databases
GtoPdb PubChem SID 252166616
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