- Advanced search
- Immuno Portal
- Malaria Portal
Molecular properties generated using the CDK
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|compound 26h [PMID: 22148278] | SB-1317 | SB1317 | TG-02 | zotiraciclib (proposed INN)|
|TG02 is an orally active multi-kinase inhibitor, with a unique activity profile against CDKs, JAK2 and FLT3 [4-5]. Like pacritinib it is a small molecule macrocycle. TG02 was rationally designed to inhibit several key signaling pathways simultaneously with the aim of maximising anti-cancer efficacy. It is being investigated for its anti-leukemic potential [2-3].
The compound is administered as the citrate salt.
|CAS Registry No.||937270-47-8 (source: PubChem)|
|GtoPdb PubChem SID||315661180|
|Search Google for chemical match using the InChIKey||VXBAJLGYBMTJCY-NSCUHMNNSA-N|
|Search Google for chemicals with the same backbone||VXBAJLGYBMTJCY|
|Search UniChem for chemical match using the InChIKey||VXBAJLGYBMTJCY-NSCUHMNNSA-N|
|Search UniChem for chemicals with the same backbone||VXBAJLGYBMTJCY|