Synonyms: AG-120 | AG120 | Tibsovo®
ivosidenib is an approved drug (FDA (2018), EMA (2023))
Compound class:
Synthetic organic
Comment: Ivosidenib (AG-120) is an orally active, selective inhibitor of isocitrate dehydrogenase 1 (IDH1) [5], in particular with activity against IDH1 R132H or R132C mutants. It is one of the compounds claimed in Agios' patent WO2013107291, where it is Compound 176 [4]. It is structurally related to AGI-5198 also from Agios.
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes (FDA (2018), EMA (2023)) |
Approved drug? | Yes. FDA (2018) | EMA (2023) |
IUPAC Name ![]() |
(2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
International Nonproprietary Names ![]() |
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INN number | INN |
10225 | ivosidenib |
Synonyms ![]() |
AG-120 | AG120 | Tibsovo® |
Database Links ![]() |
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CAS Registry No. | 1448347-49-6 (source: WHO INN record) |
DrugCentral Ligand | 5292 |
GtoPdb PubChem SID | 315661293 |
PubChem CID | 71657455 |
RCSB PDB Ligand | IV3 |
Search Google for chemical match using the InChIKey | WIJZXSAJMHAVGX-DHLKQENFSA-N |
Search Google for chemicals with the same backbone | WIJZXSAJMHAVGX |
Search PubMed clinical trials | ivosidenib |
Search PubMed titles | ivosidenib |
Search PubMed titles/abstracts | ivosidenib |
UniChem Compound Search for chemical match using the InChIKey | WIJZXSAJMHAVGX-DHLKQENFSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | WIJZXSAJMHAVGX-DHLKQENFSA-N |
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Ivosidenib (links to external site)
Cat. No. HY-18767 |