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Synonyms: AZ-191 | Compound 19 [PMID25738750]
Compound class: Synthetic organic
Comment: AZ191 is a potent and selective small molecule inhibitor of DYRK1B from AstraZeneca . Results of a 2014 study  using AZ191 indicate DYRK1B is a novel Thr(286)-CCND1(cyclinD1) kinase that acts independently of GSK3β to regulate the mammalian G1-S-phase transition. This compound is included in the Probe Portal as SGC AZ191. It was tested in preclinical studies.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|AZ-191 | Compound 19 [PMID25738750]
|CAS Registry No.
|1594092-37-1 (source: PubChem)
|GtoPdb PubChem SID
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|UniChem Compound Search for chemical match using the InChIKey
|UniChem Connectivity Search for chemical match using the InChIKey
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AZ 191 (links to external site)
Cat. No. 5232