Compound class:
Synthetic organic
Comment: The structure shown here is ER-27319 free base, when in fact the biological activity has been evaluated using the ethanedioate as represented by PubChem CID 9799508 [1]. ER-27319 is an inhibitor of spleen tyrosine kinase (Syk) [2] however, given the high concentration of compound ER-27319 required to cause half-maximal inhibition of mast cells degranulation, targets other than Syk may also be inhibited. In addition ER-27319 targets the activation of SYK mediated through FcεR1γ ITAM, suggesting there is no direct interaction with the Syk ATP pocket. Whatever the mechanism ER-27319 action is specific to mast cells.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
10-(3-aminopropyl)-3,4-dimethylacridin-9-one |
Database Links | |
BindingDB Ligand | 50396076 |
ChEMBL Ligand | CHEMBL1375018 |
GtoPdb PubChem SID | 340590241 |
PubChem CID | 9799509 |
Search Google for chemical match using the InChIKey | CFPDEQBPNROZDC-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | CFPDEQBPNROZDC |
UniChem Compound Search for chemical match using the InChIKey | CFPDEQBPNROZDC-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CFPDEQBPNROZDC-UHFFFAOYSA-N |