domperidone   Click here for help

GtoPdb Ligand ID: 965

Synonyms: Motilium® | Nauzelin® | R-33812
Approved drug
domperidone is an approved drug
Compound class: Synthetic organic
Comment: Domperidone is an orally active, peripherally acting and selective antagonist of dopamine D2 and D3 receptors.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 78.82
Molecular weight 425.16
XLogP 2.37
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2
Isomeric SMILES Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2
InChI InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
4110 domperidone
Synonyms Click here for help
Motilium® | Nauzelin® | R-33812
Database Links Click here for help
Specialist databases
GPCRdb Ligand domperidone
Other databases
BindingDB Ligand 50241107
CAS Registry No. 57808-66-9
ChEBI CHEBI:464745
ChEMBL Ligand CHEMBL219916
DrugBank Ligand DB01184
DrugCentral Ligand 945
GtoPdb PubChem SID 135650206
PubChem CID 3151
Search Google for chemical match using the InChIKey FGXWKSZFVQUSTL-UHFFFAOYSA-N
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UniChem Compound Search for chemical match using the InChIKey FGXWKSZFVQUSTL-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey FGXWKSZFVQUSTL-UHFFFAOYSA-N
Wikipedia Domperidone

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Domperidone (links to external site)
Cat. No. 2536