revamilast   Click here for help

GtoPdb Ligand ID: 9865

Synonyms: Example 26 [WO2006064355A2] | GRC 4039 | GRC-4039 | GRC4039
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Revamilast (GRC 4039) is an orally active, selective phosphodiesterase IV (PDE4) inhibitor, that was developed by Glenmark Pharmaceuticals for the treatment of multiple inflammatory conditions (rheumatoid arthritis (RA), asthma, chronic obstructive pulmonary disease (COPD) , multiple sclerosis, osteoarthritis, neuropathic pain). The chemical structure is claimed as Example 26 in Glenmark patent WO2006064355A2 [1]. GRC 4039 is no longer listed on Glenmark's development pipeline webpage.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 89.85
Molecular weight 438.99
XLogP 4.13
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES FC(Oc1ccc(c2c1oc1c2cncc1)C(=O)N=c1c(Cl)cn(cc1Cl)O)F
Isomeric SMILES FC(Oc1ccc(c2c1oc1c2cncc1)C(=O)N=c1c(Cl)cn(cc1Cl)O)F
InChI InChI=1S/C18H9Cl2F2N3O4/c19-10-6-25(27)7-11(20)15(10)24-17(26)8-1-2-13(29-18(21)22)16-14(8)9-5-23-4-3-12(9)28-16/h1-7,18,27H
InChI Key CFRXVFRHMZLQBS-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
N-(3,5-dichloro-1-hydroxypyridin-4-ylidene)-6-(difluoromethoxy)-[1]benzoxolo[3,2-c]pyridine-9-carboxamide
International Nonproprietary Names Click here for help
INN number INN
9210 revamilast
Synonyms Click here for help
Example 26 [WO2006064355A2] | GRC 4039 | GRC-4039 | GRC4039
Database Links Click here for help
CAS Registry No. 893555-90-3 (source: WHO INN record)
DrugBank Ligand DB11838
GtoPdb PubChem SID 363894159
PubChem CID 11546664
Search Google for chemical match using the InChIKey CFRXVFRHMZLQBS-UHFFFAOYSA-N
Search Google for chemicals with the same backbone CFRXVFRHMZLQBS
Search PubMed clinical trials revamilast
Search PubMed titles revamilast
Search PubMed titles/abstracts revamilast
UniChem Compound Search for chemical match using the InChIKey CFRXVFRHMZLQBS-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey CFRXVFRHMZLQBS-UHFFFAOYSA-N