Synonyms: BMS-986195 | BMS986195 | Example 223 [US20160115126A1]
Compound class:
Synthetic organic
Comment: Branebrutinib (BMS-986195) is a potent, covalent, irreversible inhibitor of the TEC family non-receptor tyrosine kinase, Bruton's tyrosine kinase (BTK) [2]. BTK is essential in antigen-dependent B cell signaling and function, and is a therapeutic target for oncology and rheumatic diseases. Branebrutinib is a clinical lead for the treatment of rheumatoid arthritis, as claimed in Bristol-Myers Squibb's patent US20160115126A1 (Example 223) [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide |
International Nonproprietary Names ![]() |
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INN number | INN |
11026 | branebrutinib |
Synonyms ![]() |
BMS-986195 | BMS986195 | Example 223 [US20160115126A1] |
Database Links ![]() |
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GtoPdb PubChem SID | 363894163 |
PubChem CID | 121293929 |
Search Google for chemical match using the InChIKey | VJPPLCNBDLZIFG-ZDUSSCGKSA-N |
Search Google for chemicals with the same backbone | VJPPLCNBDLZIFG |
Search PubMed clinical trials | branebrutinib |
Search PubMed titles | branebrutinib |
Search PubMed titles/abstracts | branebrutinib |
UniChem Compound Search for chemical match using the InChIKey | VJPPLCNBDLZIFG-ZDUSSCGKSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | VJPPLCNBDLZIFG-ZDUSSCGKSA-N |