Compound class:
Synthetic organic
Comment: Compound 1 is a photoactivatable α5β1 integrin ligand [4]. Structurally it is a selective α5β1 integrin ligand (a peptidomimetic of the RGD adhesive motif found in several extracellular matrix (ECM) proteins) linked to a 3-(4,5-Dimethoxy-2-nitrophenyl)-2-butyl ester (DMNPB) photocleavable chromophore. When intact, the compound is unable to bind the integrin, but upon exposure to light the chromophore is cleaved and the ligand then behaves as an antagonist of α5β1 interaction with ECM substrates. The photactivation of compound 1 allows precise, in situ, dose-responsive and temporal study of the role played by α5β1 integrin-dependent processes in cell adhesion and migration.
α5β1 integrin is a molecular target that plays recognised roles in tumour angiogenesis and cancer cell migration and metastasis [3,5], that is being expoilted for clinical utility in cancer indications [2,6,8]. α5β1 may also be an immune system/inflammation relevant target [1,7]. |
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Classification | |
Compound class | Synthetic organic |
Database Links | |
GtoPdb PubChem SID | 363894189 |
PubChem CID | 133081967 |
Search Google for chemical match using the InChIKey | CCIKYPZLPYEMFX-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | CCIKYPZLPYEMFX |
UniChem Compound Search for chemical match using the InChIKey | CCIKYPZLPYEMFX-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CCIKYPZLPYEMFX-UHFFFAOYSA-N |