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Endothelin-converting enzyme 2

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Target not currently curated in GtoImmuPdb

Target id: 1616

Nomenclature: Endothelin-converting enzyme 2

Abbreviated Name: ECE2

Family: M13: Neprilysin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 811 3q27.1 ECE2 endothelin converting enzyme 2
Mouse 1 763 16 B1 Ece2 endothelin converting enzyme 2
Rat - 754 11q23 Ece2 endothelin-converting enzyme 2
Database Links Click here for help
Specialist databases
MEROPS M13.003 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.71
Endogenous substrates (Human)
endothelin-1 (EDN1, P05305), endothelin-2 (EDN2, P20800), endothelin-3 (EDN3, P14138)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
S136492 Small molecule or natural product Primary target of this compound Hs Inhibition 5.3 pIC50 1
pIC50 5.3 (IC50 4.63x10-6 M) [1]
compound 1 [PMID: 18507370] Small molecule or natural product Primary target of this compound Hs Inhibition 5.2 pIC50 1
pIC50 5.2 (IC50 6.42x10-6 M) [1]

References

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1. Gagnidze K, Sachchidanand, Rozenfeld R, Mezei M, Zhou MM, Devi LA. (2008) Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem, 51 (12): 3378-87. [PMID:18507370]

How to cite this page

M13: Neprilysin: Endothelin-converting enzyme 2. Last modified on 28/07/2015. Accessed on 10/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1616.