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NLRP6

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1773

Nomenclature: NLRP6

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 892 11p15.5 NLRP6 NLR family pyrin domain containing 6
Mouse - 869 7 F5 Nlrp6 NLR family, pyrin domain containing 6
Rat - 881 1q41 Nlrp6 NLR family, pyrin domain containing 6
Previous and Unofficial Names Click here for help
CLR11.4 | NALP6 | PAN3 | NACHT, leucine rich repeat and PYD containing 6 | dual angiotensin II/vasopressin receptor | NLR family, pyrin domain containing 6 | PYPAF5 | AVR | NAVR | NAVR/AVR | NLR family
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP6 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0050727 regulation of inflammatory response ISS
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GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0050727 regulation of inflammatory response ISS
GO:0050777 negative regulation of immune response IMP
click arrow to show/hide IEA associations
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
Immuno Process:  Cellular signalling
Physiological Functions Comments
Involved in negative regulation of inflammasome signalling, regulation of mucus secretion and host intestinal microbiota composition.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Colitis
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Fatty liver disease, nonalcoholic, susceptibility to, 1; NAFLD1
OMIM: 613282
Role: 
References:  1

References

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1. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ et al.. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 482 (7384): 179-85. [PMID:22297845]

Contributors

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