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Interleukin-5 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2308

Nomenclature: Interleukin-5 receptor

Family: IL-3 receptor family

Quaternary Structure: Subunits
Interleukin 5 receptor, α subunit (Ligand-binding subunit)
Cytokine receptor common β subunit (Other subunit)
Natural/Endogenous Ligands Click here for help
IL-5 {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference
IL-5 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
Antagonists
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Ligand Sp. Action Value Parameter Reference
YM90709 Small molecule or natural product Immunopharmacology Ligand Hs Antagonist - - 1
[1]
Immunopharmacology Comments
The functional IL-5 receptor is a heterodimer consisting of the ligand binding interleukin-5 receptor subunit α (IL5RA) and CSF2RB (cytokine receptor common β subunit). CSF2RB is required for the formation of the functional receptors for IL-3, IL-5 and GM-CSF.

References

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1. Morokata T, Ida K, Yamada T. (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol, 2 (12): 1693-702. [PMID:12469943]

How to cite this page

IL-3 receptor family: Interleukin-5 receptor. Last modified on 22/03/2017. Accessed on 20/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2308.