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Oncostatin-M receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2315

Nomenclature: Oncostatin-M receptor

Family: IL-6 receptor family

Quaternary Structure: Subunits
Oncostatin M-specific receptor, β subunit (Ligand-binding subunit)
Interleukin-6 receptor, β subunit (Other subunit)
Natural/Endogenous Ligands Click here for help
oncostatin M {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference
oncostatin M {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Agonist - -
Immunopharmacology Comments
The oncostatin M receptor (from the OSMR gene) is a type I cytokine receptor. This protein heterodimerizes with the interleukin 6 signal transducer (IL6ST) to form the type II oncostatin M receptor, or with the interleukin 31 receptor α subunit (IL31RA) to form the IL-31 receptor. Germline mutations in OSMR underlie familial primary localized cutaneous amyloidosis [1], a finding that provides further understanding of the roles of oncostatin M and IL-31 in itch pathology.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Primary cutaneous amyloidosis
Description: A skin condition characterized by pruritus, skin scratching and by deposits of amyloid in the dermis.
Synonyms: familial primary localized cutaneous amyloidosis
Disease Ontology: DOID:0050639
Orphanet: ORPHA137807
Role: 
References:  1-2

References

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1. Arita K, South AP, Hans-Filho G, Sakuma TH, Lai-Cheong J, Clements S, Odashiro M, Odashiro DN, Hans-Neto G, Hans NR et al.. (2008) Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet, 82 (1): 73-80. [PMID:18179886]

2. Tanaka A, Arita K, Lai-Cheong JE, Palisson F, Hide M, McGrath JA. (2009) New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis. Br J Dermatol, 161 (6): 1217-24. [PMID:19663869]

How to cite this page

IL-6 receptor family: Oncostatin-M receptor. Last modified on 07/04/2017. Accessed on 11/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2315.