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target has curated data in GtoImmuPdb
Target id: 2319
Nomenclature: Interleukin 1 receptor, type II
| Quaternary Structure: Complexes |
| Interleukin-1 receptor, type II |
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 398 | 2q11.2 | IL1R2 | interleukin 1 receptor type 2 | |
| Mouse | 1 | 410 | 1 18.65 cM | Il1r2 | interleukin 1 receptor, type II | |
| Rat | 1 | 416 | 9q22 | Il1r2 | interleukin 1 receptor type 2 | |
| Previous and Unofficial Names |
| interleukin 1 receptor, type II | interleukin 1 receptor |
| Database Links |
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| Alphafold | P27930 (Hs), P27931 (Mm), P43303 (Rn) |
| CATH/Gene3D | 2.60.40.10 |
| Ensembl Gene | ENSG00000115590 (Hs), ENSMUSG00000026073 (Mm), ENSRNOG00000014378 (Rn) |
| Human Protein Atlas | ENSG00000115590 (Hs) |
| Pharos | P27930 (Hs) |
| UniProtKB | P27930 (Hs), P27931 (Mm), P43303 (Rn) |
| Wikipedia | IL1R2 (Hs) |
| Immunopharmacology Comments |
| IL-1R2 acts as a decoy receptor for IL-1β, thus reducing IL-1β binding/activation of IL-1R1. IL-1R2 thereby acts to down-regulate IL-1 responses [1,3], particularly when in association with the IL-1 receptor accessory protein (IL-1RAP) [2,4]. IL-1R2 is found both on the cell membrane and as a secreted protein. It is also recognised as a non-signalling receptor for IL-1α and IL-1RN. |
| Immuno Process Associations | ||
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1. Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, Bird TA, Shanebeck K, Grabstein KH, Sims JE et al.. (1994) Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. J Immunol, 153 (12): 5802-9. [PMID:7989776]
2. Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU. (1998) The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. J Immunol, 161 (12): 6871-7. [PMID:9862719]
3. Neumann D, Kollewe C, Martin MU, Boraschi D. (2000) The membrane form of the type II IL-1 receptor accounts for inhibitory function. J Immunol, 165 (6): 3350-7. [PMID:10975853]
4. Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE. (2003) The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity, 18 (1): 87-96. [PMID:12530978]
Immunoglobulin-like family of IL-1 receptors: Interleukin 1 receptor, type II. Last modified on 17/10/2018. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2319.
