Interleukin 1 receptor, type II | Immunoglobulin-like family of IL-1 receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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Interleukin 1 receptor, type II

target has curated data in GtoImmuPdb

Target id: 2319

Nomenclature: Interleukin 1 receptor, type II

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-1 receptor, type II
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 398 02q11.2 IL1R2 interleukin 1 receptor type 2
Mouse 1 410 1 18.65 cM Il1r2 interleukin 1 receptor, type II
Rat 1 416 9q21 Il1r2 interleukin 1 receptor type 2
Previous and Unofficial Names
interleukin 1 receptor, type II | interleukin 1 receptor
Database Links
CATH/Gene3D
Ensembl Gene
Human Protein Atlas
UniProtKB
Wikipedia
Immunopharmacology Comments
IL-1R2 acts as a decoy receptor for IL-1β, thus reducing IL-1β binding/activation of IL-1R1. IL-1R2 thereby acts to down-regulate IL-1 responses [1,3], particularly when in association with the IL-1 receptor accessory protein (IL-1RAP) [2,4]. IL-1R2 is found both on the cell membrane and as a secreted protein. It is also recognised as a non-signalling receptor for IL-1α and IL-1RN.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes
GO:0004908 interleukin-1 receptor activity TAS
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0070498 interleukin-1-mediated signaling pathway TAS
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GO:0004910 interleukin-1, type II, blocking receptor activity IEA
GO:0050712 negative regulation of interleukin-1 alpha secretion IEA
GO:1900016 negative regulation of cytokine production involved in inflammatory response IEA
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:1900016 negative regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:1900016 negative regulation of cytokine production involved in inflammatory response IEA

References

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1. Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, Bird TA, Shanebeck K, Grabstein KH, Sims JE et al.. (1994) Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. J. Immunol., 153 (12): 5802-9. [PMID:7989776]

2. Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU. (1998) The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. J. Immunol., 161 (12): 6871-7. [PMID:9862719]

3. Neumann D, Kollewe C, Martin MU, Boraschi D. (2000) The membrane form of the type II IL-1 receptor accounts for inhibitory function. J. Immunol., 165 (6): 3350-7. [PMID:10975853]

4. Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE. (2003) The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity, 18 (1): 87-96. [PMID:12530978]

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin 1 receptor, type II. Last modified on 17/10/2018. Accessed on 20/06/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2319.