Catechol-O-methyltransferase | Catecholamine turnover | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 2472

Nomenclature: Catechol-O-methyltransferase

Abbreviated Name: COMT

Family: Catecholamine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 271 22q11.21 COMT catechol-O-methyltransferase
Mouse - 265 16 A3 Comt catechol-O-methyltransferase
Rat - 264 11q23 Comt catechol-O-methyltransferase
Previous and Unofficial Names
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol
Description Reaction Reference
(-)-Noradrenaline -> normetanephrine
(-)-Adrenaline -> metanephrine
3,4-Dihydroxymandelic acid -> vanillylmandelic acid
Dopamine -> 3-methoxytyramine
Cofactor Species Comments Reference
S-adenosyl methionine Human

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
tolcapone Hs Inhibition 9.5 – 9.6 pKi 2
pKi 9.6 (Ki 2.7x10-10 M) soluble enzyme [2]
Description: soluble enzyme
pKi 9.5 (Ki 2.9x10-10 M) membrane-bound enzyme [2]
Description: membrane-bound enzyme
entacapone Hs Inhibition 8.7 – 9.5 pKi 2
pKi 9.5 (Ki 3x10-10 M) soluble enzyme [2]
Description: soluble enzyme
pKi 8.7 (Ki 2x10-9 M) membrane-bound enzyme [2]
Description: membrane-bound enzyme
opicapone Hs Inhibition 9.0 pKi 1
pKi 9.0 (Ki 1x10-9 M) [1]
opicapone Mm Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.5x10-9 M) [1]
opicapone Rn Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.5x10-9 M) [1]
View species-specific inhibitor tables
Clinically-Relevant Mutations and Pathophysiology
Disease:  Alcohol dependence
Disease Ontology: DOID:0050741
OMIM: 103780
Disease:  DiGeorge syndrome
Disease Ontology: DOID:11198
OMIM: 188400
Orphanet: ORPHA567
Disease:  Panic disorder 1; PAND1
Disease Ontology: DOID:594
OMIM: 167870
Disease:  Schizophrenia
Disease Ontology: DOID:5419
OMIM: 181500
Orphanet: ORPHA3140
Disease:  Velocardiofacial syndrome
Disease Ontology: DOID:12583
OMIM: 192430
Orphanet: ORPHA567


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1. Lanier M, Ambrus G, Cole DC, Davenport R, Ellery J, Fosbeary R, Jennings AJ, Kadotani A, Kamada Y, Kamran R et al.. (2014) A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT). J. Med. Chem., 57 (12): 5459-63. [PMID:24847974]

2. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melén K, Julkunen I, Taskinen J. (1995) Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 34 (13): 4202-10. [PMID:7703232]

How to cite this page

Catecholamine turnover: Catechol-O-methyltransferase. Last modified on 18/01/2016. Accessed on 23/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,