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carbonic anhydrase 7

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Target not currently curated in GtoImmuPdb

Target id: 2749

Nomenclature: carbonic anhydrase 7

Abbreviated Name: CA VII

Family: Carbonic anhydrases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 264 16q22.1 CA7 carbonic anhydrase 7
Mouse - 264 8 D3 Car7 carbonic anhydrase 7
Rat - 264 19p14 Car7 carbonic anhydrase 7
Previous and Unofficial Names Click here for help
carbonic anhydrase VII
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 4.2.1.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
histamine Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Activation - - 3
KA 37500 nM. [3]
L-histidine Small molecule or natural product Click here for species-specific activity table Hs Activation - - 5
[5]
amphetamine Small molecule or natural product Approved drug Click here for species-specific activity table Hs Activation - - 3
KA 910 nM. [3]
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ethoxzolamide Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 9.1 pKi 2
pKi 9.1 (Ki 8x10-10 M) [2]
topiramate Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 9.1 pKi 2
pKi 9.1 (Ki 9x10-10 M) [2]
methazolamide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.7 pKi 2
pKi 8.7 (Ki 2.1x10-9 M) [2]
acetazolamide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.6 pKi 1
pKi 8.6 (Ki 2.5x10-9 M) [1]
brinzolamide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.6 pKi 2
pKi 8.6 (Ki 2.8x10-9 M) [2]
chlorthalidone Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.6 pKi 4
pKi 8.6 (Ki 2.8x10-9 M) [4]
dorzolamide Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.5 pKi 2
pKi 8.5 (Ki 3.5x10-9 M) [2]
zonisamide Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.9 pKi 2
pKi 6.9 (Ki 1.17x10-7 M) [2]
indisulam Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.9 pKi 2
pKi 6.9 (Ki 1.22x10-7 M) [2]
sulpiride Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition 5.4 pKi 2
pKi 5.4 (Ki 3.63x10-6 M) [2]
Inhibitor Comments
Carbonic anhydrase (CA) inhibitors are active over a number of CA isozymes. We tag those isozymes with the highest drug affinity as the primary molecular target of each of the drugs, with the caveat that the drugs interact with other CA isozymes.

References

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1. Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R. (2010) Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg. Med. Chem. Lett., 20 (15): 4376-81. [PMID:20605094]

2. Sethi KK, Vullo D, Verma SM, Tanç M, Carta F, Supuran CT. (2013) Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety. Bioorg. Med. Chem., 21 (19): 5973-82. [PMID:23965175]

3. Tanini D, Capperucci A, Supuran CT, Angeli A. (2019) Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators. Bioorg. Chem., 87: 516-522. [PMID:30928874]

4. Temperini C, Cecchi A, Scozzafava A, Supuran CT. (2009) Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg. Med. Chem., 17 (3): 1214-21. [PMID:19119014]

5. Temperini C, Scozzafava A, Vullo D, Supuran CT. (2006) Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. Chemistry, 12 (27): 7057-66. [PMID:16807956]

How to cite this page

Carbonic anhydrases: carbonic anhydrase 7. Last modified on 25/07/2019. Accessed on 30/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2749.