Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	879	2q37.1	SP100	SP100 nuclear antigen
Mouse	-	482	1 43.6 cM	Sp100	nuclear antigen Sp100
Rat	-	342	9q35	Sp100	SP100 nuclear antigen

Database Links
Alphafold	P23497 (Hs), O35892 (Mm)
CATH/Gene3D	1.10.30.10
Ensembl Gene	ENSG00000067066 (Hs), ENSMUSG00000026222 (Mm), ENSRNOG00000022769 (Rn)
Entrez Gene	6672 (Hs), 20684 (Mm), 363269 (Rn)
Human Protein Atlas	ENSG00000067066 (Hs)
KEGG Gene	hsa:6672 (Hs), mmu:20684 (Mm), rno:363269 (Rn)
OMIM	604585 (Hs)
Pharos	P23497 (Hs)
RefSeq Nucleotide	NM_001080391 (Hs), NM_013673 (Mm), NM_001014220 (Rn)
RefSeq Protein	NP_001073860 (Hs), NP_038701 (Mm), NP_001014242 (Rn)
UniProtKB	P23497 (Hs), O35892 (Mm)
Wikipedia	SP100 (Hs)

Immuno Process Associations

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 5 GO processes GO:0034097 response to cytokine IDA GO:0034340 response to type I interferon IDA GO:0034341 response to type II interferon IDA GO:0060333 type II interferon-mediated signaling pathway IC GO:0060337 type I interferon-mediated signaling pathway IC

Immuno Process:  Inflammation GO Annotations:  Associated to 4 GO processes GO:0034340 response to type I interferon IDA GO:0034341 response to type II interferon IDA GO:0060333 type II interferon-mediated signaling pathway IC GO:0060337 type I interferon-mediated signaling pathway IC

General Comments

SP100 is a transcriptional coactivator. It interacts with and potentiates the activation of the ETS1 transcription factor [2] which is an important mediator of several physiological and pathological processes. Note that whilst SP100 does not contain a consensus bromodomain (BRD), it does contain a SAND DNA binding fold, which akin to the BRD, is involved in chromatin-associated transcriptional regulation [1]. SAND is an achronym for the range of proteins containing this binding domain: Sp100, AIRE-1, NucP41/75, DEAF-1.