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SP100 nuclear antigen

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Target not currently curated in GtoImmuPdb

Target id: 2777

Nomenclature: SP100 nuclear antigen

Family: Non-enzymatic BRD containing proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 879 2q37.1 SP100 SP100 nuclear antigen
Mouse - 482 1 43.6 cM Sp100 nuclear antigen Sp100
Rat - 342 9q35 Sp100 SP100 nuclear antigen
Database Links Click here for help
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0034340 response to type I interferon IDA
GO:0034341 response to interferon-gamma IDA
GO:0060333 interferon-gamma-mediated signaling pathway TAS
GO:0060337 type I interferon signaling pathway IC
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0034097 response to cytokine IDA
GO:0034340 response to type I interferon IDA
GO:0034341 response to interferon-gamma IDA
GO:0060333 interferon-gamma-mediated signaling pathway TAS
GO:0060337 type I interferon signaling pathway IC
General Comments
SP100 is a transcriptional coactivator. It interacts with and potentiates the activation of the ETS1 transcription factor [2] which is an important mediator of several physiological and pathological processes.
Note that whilst SP100 does not contain a consensus bromodomain (BRD), it does contain a SAND DNA binding fold, which akin to the BRD, is involved in chromatin-associated transcriptional regulation [1]. SAND is an achronym for the range of proteins containing this binding domain: Sp100, AIRE-1, NucP41/75, DEAF-1.

References

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1. Bottomley MJ, Collard MW, Huggenvik JI, Liu Z, Gibson TJ, Sattler M. (2001) The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation. Nat. Struct. Biol., 8 (7): 626-33. [PMID:11427895]

2. Wasylyk C, Schlumberger SE, Criqui-Filipe P, Wasylyk B. (2002) Sp100 interacts with ETS-1 and stimulates its transcriptional activity. Mol. Cell. Biol., 22 (8): 2687-702. [PMID:11909962]

How to cite this page

Non-enzymatic BRD containing proteins: SP100 nuclear antigen. Last modified on 13/02/2017. Accessed on 04/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2777.