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regulator of G-protein signaling 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2804

Nomenclature: regulator of G-protein signaling 1

Abbreviated Name: RGS1

Family: R4 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 209 1q31.2 RGS1 regulator of G protein signaling 1
Mouse - 209 1 62.56 cM Rgs1 regulator of G-protein signaling 1
Rat - 209 13q21 Rgs1 regulator of G-protein signaling 1
Previous and Unofficial Names Click here for help
BL34 | IER1 | IR20 | B-cell activation protein BL34 | Early response protein 1R20 | Immediate-Early Response 1, B-Cell Specific | Epididymis Secretory Protein Li 87 | HEL-S-87 | HELS87
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Associated Proteins Click here for help
G Proteins
Name References
Gαi/0 38
Gαq/11 38
Gαs (non-GAP function) 13
Interacting Proteins
Name Effect References
Calmodulin Does not directly affect GAP activity 32
G-protein α subunit Increase in the intrinsic GTPase activity, acceleration of Gα-mediated GTP hydrolysis, and signaling attenuation 38,41
GTPase Increases the activity of a GTPase hence catalyzing the hydrolysis of GTP 6,25,38
Immunopharmacology Comments
RGS1 is expressed in lymphocytes and macrophages and plays a role in leukocyte trafficking and vascular inflammation [3,10,20,30], and has been associated with multiple immune-mediated diseases [2,4,15,37].
Cell Type Associations
Immuno Cell Type:  B cells
Immuno Cell Type:  T cells
Cell Ontology Term:   T follicular helper cell (CL:0002038)
References:  5
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
References:  30
Tissue Distribution Click here for help
Species:  Human
Technique:  RT-PCR
References:  19
Lung, intestine, placenta, kidney, testis
Species:  Human
Technique:  RT-PCR
References:  19
B cells
Species:  Human
Technique:  Northern blot, in situ hybridisation
References:  12,26
Spleen B cells
Species:  Mouse
Technique:  Northern blot
References:  21
Tissue Distribution Comments
Lymphocytes and lungs: high levels of RGS1 (++++)
Intestine, kidney, placenta, and testis: moderate levels of RGS1 (+++)
Heart: low levels of RGS1 (+)
Functional Assays Click here for help
Regulation of G protein-coupled receptor (GPCR) signaling cascades/signal transduction
Species:  Human
Tissue:  Monocytes
Response measured:  Desensitization of a variety of chemotactic receptors including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors.
References:  6
Regulator of G protein signaling
Species:  Human
Response measured:  Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form.
References:  38
Physiological Functions Click here for help
Role in Leukocyte trafficking and vascular inflammation: RGS1 reduces macrophage chemotaxis and desensitization and modulates macrophage trafficking into the aortic wall.
Species:  Mouse
Tissue:  Macrophage
References:  30
Trafficking of B lymphoctes into lymph nodes and within lymph node follicles
Species:  Mouse
Tissue:  Lymph nodes/ lymph node follicles
References:  10
Rgs1 is an essential regulator of T-cell migration within lymphoid tissue, by modulating chemokine receptor activation.
Species:  Mouse
Tissue:  T cells
References:  5,20
Impairment of chemokine-induced cell migration in lymphocytes
Species:  Human
Tissue:  B lymphocytes
References:  3,22
Down regulation of B cell responses to lymphoid chemokine
Species:  Mouse
Tissue:  B lymphocytes
References:  33
Rgs1 participates in the development and function of T follicular helper (TFH) cells.
Species:  Mouse
Tissue:  T cells
References:  5
Suppression of chemotactic (CXCL12-mediated) migration and AKT activation in cultured RPMI 8226 human plasmacytoma cells and plasmablasts
Species:  Human
Tissue:  Plasmocytoma cells and plasmabalsts
References:  27
Reduced RGS1 gene expression levels in peripheral blood mononuclear cells from MS patients.
Species:  Human
Tissue:  PBMCs
References:  39
RGS1 promotes melanoma progression through regulation of Gαs‑mediated inactivation of AKT and ERK.
Species:  None
Tissue:  Cell culture
References:  39
Vascular wall Rgs1 is required for angiotensin II-mediated blood pressure control.
Species:  Mouse
References:  29
Physiological Consequences of Altering Gene Expression Click here for help
Gene is overexpressed in acute lymphocytic leukemia
Species:  Human
Tissue:  B lymphocytes
References:  12
Rgs1 knockout B lymphocytes show better adherence to lymph node high endothelial venules, better homing to lymph nodes, and more rapid movement within lymph node follicles than do wild-type B lymphocytes.
Species:  Mouse
Tissue:  Lymph nodes/lymph nodes follicles
Technique:  Gene knockout
References:  10
Rgs1 knockout mice show heightened dendritic cell migratory response to chemokines CXCL12 and CCL19.
Species:  Mouse
Tissue:  Bone marrow derived dendritic cells
Technique:  Gene knockout
References:  36
Leukocyte Rgs1 deficiency protects against aneurysm rupture.
Species:  Mouse
Tissue:  Bone marrow
Technique:  Gene knockout
References:  30
Rgs1 inhibits chemotaxis of mature B lymphocytes toward the lymphoid tissue chemokines: B lymphocyte chemoattractant (BLC) , EBV-induced molecule 1 ligand chemokine (ELC), and stromal cell-derived factor-1 (SDF-1). Regulating cell positioning in lymphoid orgas during immune response
Species:  Mouse
Tissue:  Mature B lymphocytes
Technique:  Transient transfection
References:  33
Lack of Rgs1 results in aberrant responses to the chemokines CXCL12 and CXCL13.
Species:  Mouse
Tissue:  B cells
Technique:  Gene knockout
References:  21
In Rgs1 knockouts, many of the B-cell follicles in the spleen have germinal centers even in the absence of immune stimulation, and show exagerated germinal center formation after immunization.
Species:  Mouse
Tissue:  B cell follicles in the spleen
Technique:  Gene knockout
References:  21
Immunization of Rgs1 knockout leads to abnormal trafficking of immunoglobulin-secreting cells.
Species:  Mouse
Tissue:  Plasma cells
Technique:  Gene knockout
References:  21
Immunization of Rgs1 knockout mice leads to a distorted immune architechture of the spleen and Peyer's patches.
Species:  Mouse
Tissue:  Spleen and Peyer's patches
Technique:  Gene knockout
References:  21
RGS1 expression inhibits chemoattractant-induced migration and adhesion (to a lesser extent).
Species:  Human
Tissue:  Lymphoid cells
Technique:  Transient transfection
References:  3
Suppression of Rgs1 inhibits the inflammatory response and angiogenesis by inactivating the TLR signaling pathway in rats with collagen-induced arthritis.
Species:  Rat
Technique:  shRNA
References:  13
High RGS1 expression correlates with poor prognosis in multiple myeloma.
Species:  Human
Technique:  qPCR
References:  34
Xenobiotics Influencing Gene Expression Click here for help
RGS1 is strongly inducible by phorbol esters.
Species:  Human
Tissue:  B lymphocytes
References:  11-12,24
RGS1 expression induced by Interferon B-1b (IFN-B)
Species:  Human
Tissue:  peripheral blood mononuclear cells (PBMCs)
Technique:  Immunoblotting and immunoprecpitation
References:  7
B cell treatment with anti-IgM, IL-4, cAMP, or platelet-activating factor induces the expression of RGS1.
Species:  Human
Tissue:  B lymphocytes
References:  12,24
RGS1 expression is upregulated following in vivo antigen exposure.
Species:  Mouse
Tissue:  B cells
References:  33
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Acute lymphocytic leukemia (ALL)
Description: ALL is a subtype of acute leukemia
Synonyms: Acute lymphoblastic leukemia
OMIM: 613065
References:  12
Disease:  Atherosclerosis susceptibility
Disease Ontology: DOID:1936
OMIM: 108725
References:  28,30
Disease:  Celiac disease
Disease Ontology: DOID:10608
References:  1,8-9,14-15,17,31,35,37
Disease:  Crohn's disease
Synonyms: Crohn disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
References:  8
Disease:  Diabetes mellitus, insulin-dependent; IDDM
Synonyms: Type 1 diabetes mellitus [Disease Ontology: DOID:9744]
Disease Ontology: DOID:9744
OMIM: 222100
References:  37
Disease:  Multiple sclerosis
Disease Ontology: DOID:2377
OMIM: 126200
Orphanet: ORPHA802
References:  16,18,23,40
Gene Expression and Pathophysiology Comments
RGS1 has been associated with multiple immune-mediated diseases [2,4,15,37].
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Description:  RGS1 as novel multiple sclerosis susceptibility locus.
References:  15
Type:  Single nucleotide polymorphism
Species:  Human
Description:  RGS1 SNP rs2816316 is associated with celiac disease.
SNP accession: 
References:  9
Type:  Polymorphism
Species:  Human
Description:  RGS1 polymorphism is associated with reduced attack severity of multiple sclerosis.
References:  23


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