amyloid P component, serum | Serum pentaxins | IUPHAR/BPS Guide to PHARMACOLOGY

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amyloid P component, serum

Target not currently curated in GtoImmuPdb

Target id: 2839

Nomenclature: amyloid P component, serum

Family: Serum pentaxins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 223 1q21-q23 APCS amyloid P component, serum 2-3
Mouse - 224 1 H3 Apcs serum amyloid P-component
Rat - 228 13q24 Apcs amyloid P component
Previous and Unofficial Names
PTX2 | SAP | amyloid P component
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
CPHPC Hs Binding 6.1 pIC50 4
pIC50 6.1 (IC50 9x10-7 M) [4]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference
dezamizumab Hs Binding - - 1


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1. Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ et al.. (2010) Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature, 468 (7320): 93-7. [PMID:20962779]

2. Mantzouranis EC, Dowton SB, Whitehead AS, Edge MD, Bruns GA, Colten HR. (1985) Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1. J. Biol. Chem., 260 (12): 7752-6. [PMID:2987268]

3. Ohnishi S, Maeda S, Shimada K, Arao T. (1986) Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component. J. Biochem., 100 (4): 849-58. [PMID:3029048]

4. Wermuth CG. (2004) Selective optimization of side activities: another way for drug discovery. J. Med. Chem., 47 (6): 1303-14. [PMID:14998318]

How to cite this page

Serum pentaxins: amyloid P component, serum. Last modified on 13/08/2015. Accessed on 20/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY,