Top ▲

katanin catalytic subunit A1

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2912

Nomenclature: katanin catalytic subunit A1

Family: AAA ATPases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 491 6q25.1 KATNA1 katanin catalytic subunit A1
Mouse - 491 10 A1 Katna1 katanin p60 (ATPase-containing) subunit A1
Rat - 491 1p13 Katna1 katanin catalytic subunit A1
Previous and Unofficial Names Click here for help
katanin p60 (ATPase containing) subunit A 1 | microtubule-severing protein
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.6.4.3 ATP + H(2)O <=> ADP + phosphate
Description Reaction Reference
ATP + H(2)O <=> ADP + phosphate
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0016567 protein ubiquitination IEA
General Comments
Katanin is a hydrolase enzyme composed of an ATP-dependent p60 catalytic subunit (KATNA1) and a p80 regulatory subunit (KATNB1) which targets the enzyme to the centrosome [1]. Katanin is required during meiosis and mitosis, being involved in dissasembling microtubules from their interphase structures and segregating chromatids towards the spindle pole during cell division [3].
Novel anti-cancer agents which induce microtubule fragmentation via interaction with katanin are being investigated [2]- see compound 5a [PMID: 27536893] for example.

References

Show »

1. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ. (1998) Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell, 93 (2): 277-87. [PMID:9568719]

2. Kuo TC, Li LW, Pan SH, Fang JM, Liu JH, Cheng TJ, Wang CJ, Hung PF, Chen HY, Hong TM et al.. (2016) Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin. J Med Chem, 59 (18): 8521-34. [PMID:27536893]

3. McNally FJ, Thomas S. (1998) Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. Mol Biol Cell, 9 (7): 1847-61. [PMID:9658175]

How to cite this page

AAA ATPases: katanin catalytic subunit A1. Last modified on 08/04/2021. Accessed on 20/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2912.