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absent in melanoma 2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2923

Nomenclature: absent in melanoma 2

Abbreviated Name: AIM2

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 343 1q23.1-q23.2 AIM2 absent in melanoma 2
Mouse - 354 1 H3 Aim2 absent in melanoma 2
Rat - 356 13q24 Aim2 absent in melanoma 2
Gene and Protein Information Comments
The human gene has a second reported splice variant generating a shorter protein isofom, with a shorter N-terminus (238 amino acids).
Previous and Unofficial Names Click here for help
interferon-inducible protein AIM2 | PYHIN4
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
AIM2 primarily senses cytosolic DNA and initiates formation of an inflammasome to drive IL-1β cleavage and secretion.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002218 activation of innate immune response IDA
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GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002218 activation of innate immune response IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0032611 interleukin-1 beta production IMP
GO:0032731 positive regulation of interleukin-1 beta production IDA
GO:0033209 tumor necrosis factor-mediated signaling pathway IDA
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GO:0035458 cellular response to interferon-beta IEA
General Comments
AIM2 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [1].


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1. Schattgen SA, Fitzgerald KA. (2011) The PYHIN protein family as mediators of host defenses. Immunol Rev, 243 (1): 109-18. [PMID:21884171]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): absent in melanoma 2. Last modified on 03/03/2017. Accessed on 16/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY,