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Plasmodium falciparum cyclin-dependent-like kinase CLK3

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3105

Nomenclature: Plasmodium falciparum cyclin-dependent-like kinase CLK3

Abbreviated Name: PfCLK3

Family: Antimalarial targets

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 699 CLK3 cyclin-dependent-like kinase CLK3
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Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
TCMDC-135051 Small molecule or natural product PfDd2 - - 6.9 pEC50 1
pEC50 6.9 (EC50 1.13x10-7 M) [1]
TCMDC-135051 Small molecule or natural product Pf3D7 - - 6.5 pEC50 1
pEC50 6.5 (EC50 3.2x10-7 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
TCMDC-135051 Small molecule or natural product Pb - - 6.4 pEC50 1
pEC50 6.4 (EC50 4x10-7 M) [1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Malaria Pharmacology Comments
P. falciparum cyclin-dependent-like kinase CLK3 (PfCLK3) has been validated as an antimalarial target acting at multiple parasite life stages [1]. PfCLK3 is one of four members of the cyclin-dependent like protein kinase family (PfCLK1-4) with a key role in pre-RNA splicing and processing.


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1. Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y et al.. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365 (6456). [PMID:31467193]

How to cite this page

Antimalarial targets: Plasmodium falciparum cyclin-dependent-like kinase CLK3. Last modified on 24/09/2020. Accessed on 28/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY,