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Plasmodium falciparum Niemann-Pick type C1-related protein

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3107

Nomenclature: Plasmodium falciparum Niemann-Pick type C1-related protein

Abbreviated Name: PfNCR1

Family: Transporters (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1470 NCR1 Niemann-Pick type C1-related protein
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PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
MMV009108 Small molecule or natural product Pf3D7 Parasite growth inhibition assay - - 6.3 pEC50 2
pEC50 6.3 (EC50 4.54x10-7 M) [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
The P. falciparum Niemann-Pick type C1-related protein (PfNCR1) localizes to the parasite plasma membrane and contains sequence motifs found in Niemann-Pick C1 (NPC1) proteins [2]. A number of structurally diverse compounds have validated PfNCR1 as a chemically tractable antimalarial drug target that has an essential role in maintaining membrane lipid composition during the asexual blood stage of the parasite lifecycle [1-2].

References

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1. Bhatnagar S, Nicklas S, Morrisey JM, Goldberg DE, Vaidya AB. (2019) Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis. ACS Infect Dis, 5 (4): 550-558. [PMID:30638365]

2. Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB et al.. (2019) Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. Elife, 8. [PMID:30888318]

How to cite this page

Transporters (Plasmodium spp.): Plasmodium falciparum Niemann-Pick type C1-related protein. Last modified on 13/03/2021. Accessed on 05/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3107.