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| Quaternary Structure: Subunits |
| DNA gyrase subunit A |
| DNA gyrase subunit B |
| Quaternary Structure Comments |
| DNA gyrase is a tetrameric enzyme, consisting of DNA gyrase A and B subunits assembled into a A2B2 complex of approximatively 370 kDa [3]. |
Database Links  |
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| ChEMBL Target | CHEMBL2094139 (E.coli) |
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| General Comments |
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DNA gyrase is a type II DNA topoisomerase [2] and one of two enzymes of this subclass found in bacteria, the other being DNA topoisomerase 4. DNA gyrase introduces negative supercoils in closed circular double-stranded DNA in an ATP-dependent manner. This enzyme is the clinically-validated target for a number of antibacterial drug classes, including the aminocoumarins and fluoroquinolones. |
1. Basarab GS, Gowravaram MR, Hauck SI, Zhou F. (2014) Compounds and methods for treating bacterial infections. Patent number: US8889671B2. Assignee: Entasis Therapeutics. Priority date: 23/01/2013. Publication date: 18/11/2014.
2. Gellert M, Mizuuchi K, O'Dea MH, Nash HA. (1976) DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc Natl Acad Sci U S A, 73 (11): 3872-6. [PMID:186775]
3. Vanden Broeck A, Lotz C, Ortiz J, Lamour V. (2019) Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex. Nat Commun, 10 (1): 4935. [PMID:31666516]
Bacterial protein targets: DNA gyrase. Last modified on 04/08/2023. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3219.
