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V1B receptor

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Target not currently curated in GtoImmuPdb

Target id: 367

Nomenclature: V1B receptor

Family: Vasopressin and oxytocin receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 424 1q32.1 AVPR1B arginine vasopressin receptor 1B 11,39,49
Mouse 7 421 1 E4 Avpr1b arginine vasopressin receptor 1B 62
Rat 7 425 13q13 Avpr1b arginine vasopressin receptor 1B 29,40
Previous and Unofficial Names Click here for help
Antidiuretic hormone receptor 1b | AVPR3 | V3 [39] | V1bR | Vasopressin V3 receptor | VPR3 | vasopressin V1b receptor | V3/V1b pituitary vasopressin receptor
Database Links Click here for help
Specialist databases
GPCRdb v1br_human (Hs), v1br_mouse (Mm), v1br_rat (Rn)
Other databases
Alphafold P47901 (Hs), Q9WU02 (Mm), P48974 (Rn)
ChEMBL Target CHEMBL1921 (Hs), CHEMBL2659 (Rn)
DrugBank Target P47901 (Hs)
Ensembl Gene ENSG00000198049 (Hs), ENSMUSG00000026432 (Mm)
Entrez Gene 553 (Hs), 26361 (Mm), 29462 (Rn)
Human Protein Atlas ENSG00000198049 (Hs)
KEGG Gene hsa:553 (Hs), mmu:26361 (Mm), rno:29462 (Rn)
OMIM 600264 (Hs)
Pharos P47901 (Hs)
RefSeq Nucleotide NM_000707 (Hs), NM_011924 (Mm), NM_017205 (Rn)
RefSeq Protein NP_000698 (Hs), NP_036054 (Mm), NP_058901 (Rn)
UniProtKB P47901 (Hs), Q9WU02 (Mm), P48974 (Rn)
Wikipedia AVPR1B (Hs)
Natural/Endogenous Ligands Click here for help
oxytocin {Sp: Human, Mouse, Rat}
vasopressin {Sp: Human, Mouse, Rat}
Comments: Vasopressin is the principal endogenous agonist
Potency order of endogenous ligands (Human)
vasopressin (AVP, P01185) > oxytocin (OXT, P01178)  [1,8,13,22,33,41,51,55]

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[3H]AVP (human, mouse, rat) Peptide Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist 8.6 – 9.6 pKd 13,41,50-51,55
⤷ pKd 8.6 – 9.6 (Kd 2.51x10-9 – 2.5x10-10 M) [13,41,50-51,55]
[3H]d[Cha4]AVP Peptide Ligand is labelled Ligand is radioactive Hs Full agonist 8.9 pKd 13
⤷ pKd 8.9 [13]
[3H]OT (human, mouse, rat) Peptide Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist 5.8 pKd 55
⤷ pKd 5.8 [55]
vasopressin {Sp: Human, Mouse, Rat} Peptide Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 9.9 pKi 41
⤷ pKi 9.9 [41]
d[Leu4]LVP Peptide Hs Full agonist 9.8 pKi 37
⤷ pKi 9.8 [37]
d[Leu4,Dap8]VP Peptide Click here for species-specific activity table Rn Full agonist 9.4 pKi 37
⤷ pKi 9.4 [37]
d[Cha4]AVP Peptide Click here for species-specific activity table Hs Full agonist 9.0 – 9.7 pKi 13,22
⤷ pKi 9.0 – 9.7 [13,22]
d[D-Phe2]AVP Peptide Click here for species-specific activity table Hs Full agonist 9.3 pKi 13
⤷ pKi 9.3 [13]
d[Leu4]AVP Peptide Click here for species-specific activity table Hs Full agonist 9.3 pKi 8
⤷ pKi 9.3 [8]
vasopressin {Sp: Human, Mouse, Rat} Peptide Approved drug Primary target of this compound Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 9.0 – 9.5 pKi 1,8,13,22,33,41,50-51,55,67
⤷ pKi 9.0 – 9.5 [1,8,13,22,33,41,50-51,55,67]
d[Cha4,Dab8]VP Peptide Click here for species-specific activity table Rn Full agonist 9.1 pKi 37
⤷ pKi 9.1 [37]
[Val4]AVP Peptide Click here for species-specific activity table Hs Full agonist 9.0 pKi 13
⤷ pKi 9.0 [13]
dAVP Peptide Click here for species-specific activity table Hs Full agonist 8.2 – 9.4 pKi 8,13,51
⤷ pKi 8.2 – 9.4 [8,13,51]
d[Cha4]LVP Peptide Click here for species-specific activity table Rn Full agonist 8.7 pKi 37
⤷ pKi 8.7 [37]
LVP {Sp: Pig} Peptide Click here for species-specific activity table Hs Full agonist 8.5 pKi 55
⤷ pKi 8.5 [55]
dVDAVP Peptide Click here for species-specific activity table Hs Full agonist 7.6 – 9.0 pKi 13,55
⤷ pKi 7.6 – 9.0 [13,55]
arginine vasotocin Peptide Click here for species-specific activity table Hs Full agonist 8.0 pKi 55
⤷ pKi 8.0 [55]
desmopressin Peptide Approved drug Click here for species-specific activity table Rn Partial agonist 8.0 pKi 41
⤷ pKi 8.0 [41]
desmopressin Peptide Approved drug Click here for species-specific activity table Hs Full agonist 7.7 – 8.2 pKi 8,33,41,55
⤷ pKi 7.7 – 8.2 [8,33,41,55]
d[D-Pal2]AVP Peptide Click here for species-specific activity table Hs Full agonist 7.3 – 7.9 pKi 13,43,55
⤷ pKi 7.3 – 7.9 (Ki 5x10-8 – 1.38x10-8 M) [13,43,55]
oxytocin {Sp: Human, Mouse, Rat} Peptide Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 5.7 – 7.0 pKi 22,41,50-51,55
⤷ pKi 5.7 – 7.0 [22,41,50-51,55]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
nelivaptan Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.4 – 9.3 pKi 22,46
⤷ pKi 8.4 – 9.3 [22,46]
OH-LVA Peptide Click here for species-specific activity table Hs Antagonist 8.7 pKi 55
⤷ pKi 8.7 [55]
d[Pen1,Tyr(Me)2]AVP Peptide Click here for species-specific activity table Hs Antagonist 8.2 pKi 51
⤷ pKi 8.2 [51]
[Phaa1,D-Tyr(Me)2,Arg6,Tyr-NH29]AVP Peptide Click here for species-specific activity table Hs Antagonist 8.0 pKi 55
⤷ pKi 8.0 [55]
[Phaa1,D-Tyr2,Val4,Arg6,Arg-NH29]AVP Peptide Click here for species-specific activity table Hs Antagonist 7.8 pKi 55
⤷ pKi 7.8 [55]
[Phaa1,D-Tyr(Et)2,Lys6,des-Gly9]AVP Peptide Click here for species-specific activity table Hs Antagonist 7.5 pKi 55
⤷ pKi 7.5 [55]
relcovaptan Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.3 – 7.3 pKi 22,51,55,57
⤷ pKi 6.3 – 7.3 [22,51,55,57]
d(CH2)5[Tyr(Me)2]AVP Peptide Click here for species-specific activity table Hs Antagonist 6.4 – 7.0 pKi 41,50-51,55
⤷ pKi 6.4 – 7.0 [41,50-51,55]
[tBaa1,D-Tyr(Et)2,Val4,Lys6,Arg-NH28,des-Gly9]AVP Peptide Click here for species-specific activity table Hs Antagonist 6.4 pKi 55
⤷ pKi 6.4 [55]
atosiban Peptide Approved drug Click here for species-specific activity table Hs Antagonist 6.2 – 6.6 pKi 9,45
⤷ pKi 6.2 – 6.6 [9,45]
d(CH2)5[D-Ile2,Ile4,Ala-NH2]AVP Peptide Click here for species-specific activity table Hs Antagonist 6.3 pKi 55
⤷ pKi 6.3 [55]
d(CH2)5[D-Ile2,Ile4,Ala-NH29]AVP Peptide Click here for species-specific activity table Hs Antagonist 6.2 pKi 55
⤷ pKi 6.2 [55]
[Phaa1,D-Tyr(Et)2,Val4,Lys6,Tyr-NH28,des-Gly9]AVP Peptide Click here for species-specific activity table Hs Antagonist 6.1 pKi 55
⤷ pKi 6.1 [55]
d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP Peptide Click here for species-specific activity table Hs Antagonist 5.7 pKi 51
⤷ pKi 5.7 [51]
d(CH2)5[Tyr(Me)2,Thr4,Phe(3I,4N3)-NH29]OVT Peptide Click here for species-specific activity table Hs Antagonist 5.2 pKi 6
⤷ pKi 5.2 [6]
d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT Peptide Click here for species-specific activity table Hs Antagonist 5.0 pKi 55
⤷ pKi 5.0 [55]
mozavaptan Small molecule or natural product Click here for species-specific activity table Hs Antagonist 4.8 pKi 55
⤷ pKi 4.8 [55]
YM 471 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 4.8 pKi 57
⤷ pKi 4.8 [57]
YM 218 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 4.6 pKi 53
⤷ pKi 4.6 [53]
d(CH2)5[Tyr(Me)2,Thr4]OVT Peptide Click here for species-specific activity table Hs Antagonist 4.5 pKi 55
⤷ pKi 4.5 [55]
satavaptan Small molecule or natural product Click here for species-specific activity table Hs Antagonist 4.3 pKi 57
⤷ pKi 4.3 [57]
[3H]nelivaptan Small molecule or natural product Ligand is labelled Ligand is radioactive Hs Antagonist - -
⤷
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  44
Tissue Distribution Click here for help
Pancreas: islets of Langerhans (α-glucagon, β-insulin and δ-somatostatin cells).
Species:  Human
Technique:  Immunohistochemistry.
References:  15
Pancreas.
Species:  Human
Technique:  RT-PCR.
References:  15
Brain: CA2 region of the hippocampus
Species:  Human
Technique:  In situ hybridisation and RT-PCR.
References:  69
Adrenal medulla.
Species:  Human
Technique:  RT-PCR.
References:  19
Pituitary
Species:  Human
Technique:  Northern blotting.
References:  49
Pituitary, kidney.
Species:  Human
Technique:  RT-PCR.
References:  11
Pituitary, brain (fibre projections mainly in CA2 and other hippocampal strata)
Species:  Mouse
Technique:  Receptor autoradiography
References:  30
Pancreatic islet cells.
Species:  Mouse
Technique:  RT-PCR.
References:  35
Pituitary > hypothalamus, brain, adrenal, pancreas, colon.
Species:  Mouse
Technique:  RT-PCR.
References:  62
Brain: CA2 region of the hippocampus
Species:  Mouse
Technique:  In situ hybridisation and RT-PCR.
References:  69
Brain: olfactory bulb (mitral cell layer), suprachiasmatic nucleus, piriform cortex, CA2, dorsomedial hypothalamic nucleus (compact region), tenia tecta, dorsal raphe, supraoptic nucleus, CA3, pontine nucleus, tuberomammillary nucleus > lateral reticular nucleus, substantia nigra pars compacta, CA1, dorsal motor nucleus of vagus, entorhinal cortex, agranular insular cortex, red nucleus (magnocellular), trigeminal nucleus (oral), ventral tegmental area, posteromedial cortical amgydala nucleus, amgydala-piriform transition, facial nucleus > inferior olivary nucleus, lateral hypothalamus, ventrolateral orbital cortex, periventricular hypothalamic area, lateral orbital cortex, locus coeruleus, trigeminal nucleus (interpola), olfactory bulb (external plexiform layer), dorsal premammillary nucleus, posterolateral cortical amgydala nucleus, gigantocellular reticular nucleus.
Species:  Rat
Technique:  in situ hybridisation.
References:  58
Pituitary, brain (fibre projections mainly in CA2 and other hippocampal strata)
Species:  Rat
Technique:  Receptor autoradiography
References:  30
Brain: Olfactory system (olfactory tubercle > piriform cortex, nucleus of the lateral olfactory tract), cerebral cortex (cingulate cortex, frontal cortex > parietal cortex), basal forebrain (bed nucleus of the stria terminalis, diagonal band of Broca, fundud striati, organum vasculosum of the lamina terminalis), basal ganglia (caudate putamen > nucleus accumbens), lateral septum (taenia tecta), hippocampal formation (fields of Ammon's horn > dentate gyrus), amygdala (anterior cortical amygdaloid nucleus, posteromedial cortical amygdaloid nucleus), subfornical organ, medial habenula, habenular commissure, thalamus (ventrolateral nucleus, ventral posterolateral nucleus, ventral posteromedial nucleus, paraventricular nucleus, posterior nuclear group, periventricular nucleus), hypothalamus (mediam eminence > premammilary nuclei, mammilary nuclei > medial preoptic area, periventricular nucleus, tuber cinerum, medial forebrain bundle), pons and medulla (ventral cochlea nucleus, nucleus trapezoid body), cerebellum (granule cell layers, white matter).
Species:  Rat
Technique:  Immunohistochemistry.
References:  23
Pituitary.
Species:  Rat
Technique:  Radioligand binding.
References:  2,18,25,30
Brain, pituitary, kidney, thymus, heart, lung, spleen, uterus, breast.
Species:  Rat
Technique:  RT-PCR, Northern blotting and in situ hybridisation.
References:  29
Adrenal medulla.
Species:  Rat
Technique:  RT-PCR.
References:  20,56
Brain: predominantly CA2 region of the hippocampus; levels unaffected by restraint stress or adrenalectomy.
Species:  Rat
Technique:  In situ hybridisation and RT-PCR.
References:  69
Pituitary.
Species:  Rat
Technique:  Northern Blotting and in situ hybridisation.
References:  38
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of Ca2+ levels in CHO cells transfected with the human V1B receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of Ca2+ mobilisation.
References:  51
Measurement of IP accumulation in COS cells transfected with the human V1B receptor.
Species:  Human
Tissue:  COS cells.
Response measured:  Stimulation of IP accumulation.
References:  11
Measurement of IP accumulation in CHO cells transfected with the mouse V1B receptor.
Species:  Mouse
Tissue:  CHO cells.
Response measured:  Stimulation of IP accumulation.
References:  62
Measurement of IP accumulation in CHO cells transfected with the rat V1B receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Stimulation of IP accumulation.
References:  29
Measurement of IP accumulation in CHO cells transfected with the human V1B receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of IP accumulation.
References:  55
Measurement of MAP kinase activation in CHO cells transfected with the human V1B receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of MAP kinase activation.
References:  52
Measurement of chloride current in Xenopus oocytes transfected with the human V1B receptor.
Species:  Human
Tissue:  Xenopus oocytes.
Response measured:  Activation of Ca2+-dependent chloride current.
References:  49
Measurement of Ca2+ levels in rat adrenal glomerulosa cell primary cultures endogenously expressing the V1B receptor.
Species:  Rat
Tissue:  Adrenal glomerulosa cell primary cultures.
Response measured:  Stimulation of Ca2+ mobilisation.
References:  20
Measurement of arachidonic acid release in CHO cells transfected with the human V1B receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of arachidonic acid release.
References:  55
Measurement of [3H]thymidine incorporation in CHO cells transfected with the human V1B receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of thymidine incorporation (observed with medium density V1B expression, not with high density expression).
References:  52,55
Measurement of cAMP accumulation in CHO cells transfected with the human V1B receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation (observed only with high density V1B expression).
References:  55
Measurement of MAP kinase activation in CHO cells transfected with the rat V1B receptor.
Species:  Rat
Tissue:  CHO cells
Response measured:  Stimulation of MAP kinase activation
References:  30
Physiological Functions Click here for help
Release of adrenocorticotropin.
Species:  Rat
Tissue:  Anterior pituitary cells.
References:  42,59
Potentiation of CRF-induced secretion of adrenocorticotropin.
Species:  Rat
Tissue:  Anterior pituitary cells.
References:  3-4,59
Stimulation of insulin release.
Species:  Mouse
Tissue:  Pancreatic islet cells.
References:  35
Stimulation of insulin release.
Species:  Rat
Tissue:  Perfused pancreas.
References:  27
Stimulation of glucagon secretion.
Species:  Mouse
Tissue:  Pancreatic islets.
References:  17
Regulation of catecholamine secretion.
Species:  Rat
Tissue:  Adrenal medullary primary cultures.
References:  20
Regulation of the hypothalamic-pituitary-adrenal axis.
Species:  Mouse
Tissue:  In vivo.
References:  54
Regulation of stress-induced catecholamine release.
Species:  Mouse
Tissue:  In vivo.
References:  24
Physiological Consequences of Altering Gene Expression Click here for help
V1B receptor knockout mice exhibit reduced adrenocorticotropin secretion to acute insulin-induced hypoglycaemia and to repeated restraint stress compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  31
V1B receptor knockout mice exhibit reduced aggression compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  64
V1B receptor knockout mice exhibit reduced basal adrenocorticotropin and corticosterone levels, an impaired rise in adrenocorticotropin in response to AVP and no difference in CRF-induced adrenocorticotropin release compared to wild-type mice.
Under stressed conditions, adrenocorticotropin release is supressed in V1B receptor knockout mice compared to wild-type.
Primary cultured pituitary cells from V1B knockout mice exhibit reduced adrenocorticotropin release in response to AVP.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  54
V1B receptor knockout mice exhibit reduced levels of prepulse inhibition of the startle reflex and reduced acoustic startle response.
They also have reduced basal levels of extracellular dopamine in the medial frontal cortex.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  14
V1B receptor knockout mice exhibit altered stres-induced catecholamine release compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  24
V1B receptor knockout mice do exhibit OT- and AVP-induced glucagon secretion as seen in wild-type mice due to compensation by the OT receptor.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  17
V1B receptor knockout mice exhibit normal behavioural responses to acute, intoxicating doses of ethanol compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  7
V1B receptor knockout mice exhibit reduced adrenocorticotropin and corticosterone levels in response to lipopolysaccharide challenge and ethanol administration compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  32
V1B receptor knockout mice exhibit increased water intake and urine volume, and decreased body temperature and oxygen consumption compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  10
V1B receptor knockout mice exhibit a reduced attack component of aggressive behaviour compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  63
V1B receptor knockout mice exhibit enhanced sensitivity to insulin compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16
V1B receptor knockout mice exhibit an impaired Bruce effect (process by which exposure to chemosensory cues from an unfamiliar male terminates pregnancy in a recently mated female) compared to wild-type (and vasopressin V1A receptor knockout) mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  65
V1B receptor knockout mice exhibit reduced ACTH (but not necessarily corticosterone) responses to acute and repeated restraint, forced swimming and novel environment stress.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embyronic stem cells
References:  47
V1B receptor knockout mice exhibit impaired AVP-potentiated, CRF-induced insulin secretion.
Species:  Mouse
Tissue:  Isolated pancreatic β-islet cells
Technique:  Gene targeting in embryonic stem cells
References:  34
V1B receptor knockout mice have reduced ACTH and corticosterone responses to antidepressant administration.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells
References:  48
V1B receptor and V1A receptor double knockout mice exhibit altered circadian rhythm behaviour, clock gene expression, and body temperature.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells
References:  66
V1B receptor knockout mice exhibit reduced aggression; behaviour restored by intra-hippocampal CA2 injection of a lentiviral V1B receptor construct.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells; lentiviral-based V1B receptor functional rescue
References:  36
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Avpr1btm1Wsy Avpr1btm1Wsy/Avpr1btm1Wsy
involves: 129S4/SvJae * C57BL/6		 MGI:1347010  MP:0001360 abnormal social investigation PMID: 12399951 
Avpr1btm1Wsy Avpr1btm1Wsy/Avpr1btm1Wsy
involves: 129S4/SvJae * C57BL/6		 MGI:1347010  MP:0005656 decreased aggression PMID: 12399951 
Avpr1btm1Gzt Avpr1btm1Gzt/Avpr1btm1Gzt
involves: 129/Sv * C57BL/6J		 MGI:1347010  MP:0002664 decreased circulating adrenocorticotropin level PMID: 14722621 
Avpr1btm1Gzt Avpr1btm1Gzt/Avpr1btm1Gzt
involves: 129/Sv * C57BL/6J		 MGI:1347010  MP:0002665 decreased circulating corticosterone level PMID: 14722621 
Avpr1btm1Wsy Avpr1btm1Wsy/Avpr1btm1Wsy
involves: 129S4/SvJae * C57BL/6		 MGI:1347010  MP:0002781 increased circulating testosterone level PMID: 12399951 
Avpr1btm1Dgen Avpr1btm1Dgen/Avpr1btm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:1347010  MP:0002906 increased susceptibility to pharmacologically induced seizures
Avpr1btm1Gzt Avpr1btm1Gzt/Avpr1btm1Gzt
involves: 129/Sv * C57BL/6J		 MGI:1347010  MP:0002768 small adrenal glands PMID: 14722621 
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Description:  A SNP in the exonic region of the V1B receptor gene may contribute (with CRFR1 polymorphisms) to the susceptibility to panic disorder.
Amino acid change:  R364H
SNP accession:  rs28632197
References:  26
Type:  Single nucleotide polymorphism
Species:  Human
Description:  A SNP in the V1B receptor gene may be associated with the vulnerability to attention deficit hyperactivity disorder.
SNP accession:  rs28373064
References:  61
Type:  Single nucleotide polymorphism
Species:  Human
Description:  A SNP in the V1B receptor gene may alter susceptibility to bipolar disorder with psychotic features.
Nucleotide change:  C>T
SNP accession:  rs28536160
References:  28
Type:  Single nucleotide polymorphism
Species:  Human
Description:  A SNP in the V1B receptor gene may be associated with mood and anxiety outcomes in suicidal attempts.
Amino acid change:  G191R
SNP accession:  rs33990840
References:  5
Type:  Single nucleotide polymorphism
Species:  Human
Description:  A SNP in the V1B receptor gene may be associated with childhood-onset mood disorders.
Amino acid change:  K65N
SNP accession:  rs35369693
References:  12
Type:  Single nucleotide polymorphism
Species:  Human
Description:  A SNP in the V1B receptor gene may contribute to protection against recurrent major depression.
References:  60
General Comments
AVP released in the portal blood acts as a potent secretagogue of adrenocorticotropin (ACTH) through its action on the V1B receptor. This receptor mediates the release of ACTH and beta-endorphin from the anterior pituitary through the mobilisation of intracellular calcium by phosphatidyl inositol hydrolysis [18]. The V1B receptor heterodimerises with the corticotropin-releasing factor type 1 receptor in vitro [68]. The presence of the V1B receptor has also been reported in other organs such as the brain, the adrenals, and the pancreas [29]. A potent, selective, and orally active V1B receptor antagonist has been recently described. It has antidepressant- and anxiolytic-like properties [21].

References

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1. Akerlund M, Bossmar T, Brouard R, Kostrzewska A, Laudanski T, Lemancewicz A, Serradeil-Le Gal C, Steinwall M. (1999) Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women. Br J Obstet Gynaecol, 106 (10): 1047-53. [PMID:10519430]

2. Antoni FA. (1984) Novel ligand specificity of pituitary vasopressin receptors in the rat. Neuroendocrinology, 39: 186-188. [PMID:6089020]

3. Antoni FA, Holmes MC, Makara GB, Kárteszi M, László FA. (1984) Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor. Peptides, 5: 519-522. [PMID:6089144]

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