K<sub>2P</sub>7.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 519

Nomenclature: K2P7.1

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 307 11q13 KCNK7 potassium two pore domain channel subfamily K member 7 2
Mouse 4 2 343 19 B2 Kcnk7 potassium channel, subfamily K, member 7 1-2
Rat 4 2 311 1q43 Kcnk7 potassium two pore domain channel subfamily K member 7
Previous and Unofficial Names
kcnk8 | Knot | Mlk3 | potassium channel, subfamily K, member 7 | potassium channel, two pore domain subfamily K, member 7 | potassium channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Functional Characteristics
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcnk7tm1Dgen Kcnk7tm1Dgen/Kcnk7tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:1341841  MP:0002169 no abnormal phenotype detected PMID: 18572259 
General Comments
The product of this gene has not yet been shown to form a functional channel. Five splice variants have been identified in human. The mouse isolate was cited as kcnk6 and then kcnk8 but is now called K2P7 due to its homology and syntenic location to human KCNK7 [1].


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1. Bockenhauer D, Nimmakayalu MA, Ward DC, Goldstein SA, Gallagher PG. (2000) Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. Gene, 261 (2): 365-72. [PMID:11167025]

2. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M. (1999) Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J. Biol. Chem., 274 (17): 11751-60. [PMID:10206991]


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