K<sub>2P</sub>17.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 526

Nomenclature: K2P17.1

Abbreviated Name: TALK2

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 332 6p21.1-2 KCNK17 potassium two pore domain channel subfamily K member 17 3
Previous and Unofficial Names
TALK2 | TASK4 | potassium channel, subfamily K, member 17 | potassium channel, two pore domain subfamily K, member 17
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Functional Characteristics
Background current

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Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
NO Hs - - - - - 1
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
chloroform Hs - - - 7x10-4 - 9x10-4 - 3
Conc range: 7x10-4 - 9x10-4 M [3]
Tissue Distribution
Heart, lung, liver, pancreas.
Species:  Human
References:  3
Clinically-Relevant Mutations and Pathophysiology
Disease:  Severe progressive cardiac conduction disorder
References:  2
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human G88R 262G>A Gain of function mutation 2
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. The open probability of K2P17.1 increases as pHo is raised above physiological levels, see K2P16.1.


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1. Duprat F, Girard C, Jarretou G, Lazdunski M. (2005) Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. J. Physiol. (Lond.), 562 (Pt 1): 235-44. [PMID:15513946]

2. Friedrich C, Rinné S, Zumhagen S, Kiper AK, Silbernagel N, Netter MF, Stallmeyer B, Schulze-Bahr E, Decher N. (2014) Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder. EMBO Mol Med, 6 (7): 937-51. [PMID:24972929]

3. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem. Biophys. Res. Commun., 282 (1): 249-56. [PMID:11263999]


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