Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	2	332	6p21.2	KCNK17	potassium two pore domain channel subfamily K member 17	3

Previous and Unofficial Names

TALK2 | TASK4 | potassium channel, subfamily K, member 17 | potassium channel, two pore domain subfamily K, member 17

Database Links
Alphafold	Q96T54 (Hs)
ChEMBL Target	CHEMBL4523433 (Hs)
Ensembl Gene	ENSG00000124780 (Hs)
Entrez Gene	89822 (Hs)
Human Protein Atlas	ENSG00000124780 (Hs)
KEGG Gene	hsa:89822 (Hs)
OMIM	607370 (Hs)
Pharos	Q96T54 (Hs)
RefSeq Nucleotide	NM_031460 (Hs)
RefSeq Protein	NP_113648 (Hs)
UniProtKB	Q96T54 (Hs)
Wikipedia	KCNK17 (Hs)

Functional Characteristics
Background current

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Activators
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference NO Hs - - - - - 1 ⤷ [1]

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference chloroform Hs - - - 7x10-4 - 9x10-4 - 3 ⤷ Conc range: 7x10-4 - 9x10-4 M [3]

Tissue Distribution
Heart, lung, liver, pancreas. Species:  Human Technique:  References:  3

Clinically-Relevant Mutations and Pathophysiology
Disease:  Severe progressive cardiac conduction disorder References:  2 Click column headers to sort Type Species Amino acid change Nucleotide change Description Reference Missense Human G88R 262G>A Gain of function mutation 2

General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. The open probability of K2P17.1 increases as pHo is raised above physiological levels, see K2P16.1.