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K2P17.1

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Target not currently curated in GtoImmuPdb

Target id: 526

Nomenclature: K2P17.1

Abbreviated Name: TALK2

Family: Two P domain potassium channels

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 332 6p21.2 KCNK17 potassium two pore domain channel subfamily K member 17 3
Previous and Unofficial Names Click here for help
TALK2 | TASK4 | potassium channel, subfamily K, member 17 | potassium channel, two pore domain subfamily K, member 17
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics Click here for help
Background current

Download all structure-activity data for this target as a CSV file go icon to follow link

Activators
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
NO Approved drug Click here for species-specific activity table Hs - - - - - 1
[1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
chloroform Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs - - - 7x10-4 - 9x10-4 - 3
Conc range: 7x10-4 - 9x10-4 M [3]
Tissue Distribution Click here for help
Heart, lung, liver, pancreas.
Species:  Human
Technique: 
References:  3
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Severe progressive cardiac conduction disorder
References:  2
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human G88R 262G>A Gain of function mutation 2
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. The open probability of K2P17.1 increases as pHo is raised above physiological levels, see K2P16.1.

References

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1. Duprat F, Girard C, Jarretou G, Lazdunski M. (2005) Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. J Physiol (Lond.), 562 (Pt 1): 235-44. [PMID:15513946]

2. Friedrich C, Rinné S, Zumhagen S, Kiper AK, Silbernagel N, Netter MF, Stallmeyer B, Schulze-Bahr E, Decher N. (2014) Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder. EMBO Mol Med, 6 (7): 937-51. [PMID:24972929]

3. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem Biophys Res Commun, 282 (1): 249-56. [PMID:11263999]

Contributors

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