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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 635 | 1p13.3 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | 10-11 |
| Mouse | 6 | 1 | 628 | 3 46.83 cM | Kcnc4 | potassium voltage gated channel, Shaw-related subfamily, member 4 | 11 |
| Rat | 6 | 1 | 625 | 2q34 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | 11 |
| Previous and Unofficial Names |
| Raw3 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | Kcr2-4 | potassium voltage gated channel, Shaw-related subfamily, member 4 | potassium voltage-gated channel, Shaw-related subfamily, member 4 | potassium channel, voltage gated Shaw related subfamily C, member 4 | potassium channel, voltage gated Shaw-related subfamily C, member 4 | potassium voltage gated channel |
| Database Links |
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| Alphafold | Q03721 (Hs), Q8R1C0 (Mm), Q63734 (Rn) |
| Ensembl Gene | ENSG00000116396 (Hs), ENSMUSG00000027895 (Mm), ENSRNOG00000060988 (Rn) |
| Entrez Gene | 3749 (Hs), 99738 (Mm), 684516 (Rn) |
| Human Protein Atlas | ENSG00000116396 (Hs) |
| KEGG Gene | hsa:3749 (Hs), mmu:99738 (Mm), rno:684516 (Rn) |
| OMIM | 176265 (Hs) |
| Pharos | Q03721 (Hs) |
| RefSeq Nucleotide | NM_004978 (Hs), NM_145922 (Mm), NM_001122776 (Rn) |
| RefSeq Protein | NP_004969 (Hs), NP_666034 (Mm), NP_001116248 (Rn) |
| UniProtKB | Q03721 (Hs), Q8R1C0 (Mm), Q63734 (Rn) |
| Wikipedia | KCNC4 (Hs) |
| Associated Proteins |
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| Functional Characteristics |
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| KA | |
| Ion Selectivity and Conductance |
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| Voltage Dependence |
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| Associated subunits (Human) |
| MiRP2 is an associated subunit for Kv3.4 |
Download all structure-activity data for this target as a CSV file 
| Gating inhibitors
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Channel Blockers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Channel Blocker Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The specificity of BDS-I for Kv3.4 has been questioned. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Clinically-Relevant Mutations and Pathophysiology
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| Gene Expression and Pathophysiology
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| General Comments |
| Kv3.4 belongs to the mammalian Shaw-related family. |
1. Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, Goldstein SA. (2001) MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell, 104 (2): 217-31. [PMID:11207363]
2. Abbott GW, Butler MH, Goldstein SA. (2006) Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. FASEB J, 20 (2): 293-301. [PMID:16449802]
3. Diochot S, Schweitz H, Béress L, Lazdunski M. (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J Biol Chem, 273 (12): 6744-9. [PMID:9506974]
4. Gordon E, Cohen JL, Engel R, Abbott GW. (2006) 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol, 69 (3): 718-26. [PMID:16317109]
5. Göpel SO, Kanno T, Barg S, Rorsman P. (2000) Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets. J Physiol (Lond.), 528 (Pt 3): 497-507. [PMID:11060127]
6. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B et al.. (1998) Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem, 273 (10): 5851-7. [PMID:9488722]
7. Pannaccione A, Boscia F, Scorziello A, Adornetto A, Castaldo P, Sirabella R, Taglialatela M, Di Renzo GF, Annunziato L. (2007) Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol Pharmacol, 72 (3): 665-73. [PMID:17495071]
8. Rettig J, Wunder F, Stocker M, Lichtinghagen R, Mastiaux F, Beckh S, Kues W, Pedarzani P, Schröter KH, Ruppersberg JP. (1992) Characterization of a Shaw-related potassium channel family in rat brain. EMBO J, 11 (7): 2473-86. [PMID:1378392]
9. Riazanski V, Becker A, Chen J, Sochivko D, Lie A, Wiestler OD, Elger CE, Beck H. (2001) Functional and molecular analysis of transient voltage-dependent K+ currents in rat hippocampal granule cells. J Physiol (Lond.), 537 (Pt 2): 391-406. [PMID:11731573]
10. Rudy B, Sen K, Vega-Saenz de Miera E, Lau D, Ried T, Ward DC. (1991) Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21. J Neurosci Res, 29 (3): 401-12. [PMID:1920536]
11. Schröter KH, Ruppersberg JP, Wunder F, Rettig J, Stocker M, Pongs O. (1991) Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain. FEBS Lett, 278 (2): 211-6. [PMID:1840526]
12. Suzuki H, Momoi N, Ono T, Maeda S, Shikama Y, Matsuoka I, Suzuki H, Kimura J. (2005) Inhibitory effect of thiopental on ultra-rapid delayed rectifier K+ current in H9c2 cells. J Pharmacol Sci, 99 (2): 177-84. [PMID:16217144]
13. Weiser M, Vega-Saenz de Miera E, Kentros C, Moreno H, Franzen L, Hillman D, Baker H, Rudy B. (1994) Differential expression of Shaw-related K+ channels in the rat central nervous system. J Neurosci, 14 (3 Pt 1): 949-72. [PMID:8120636]
