K<SUB>v</SUB>9.3 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 569

Nomenclature: Kv9.3

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 491 2p24 KCNS3 potassium voltage-gated channel modifier subfamily S member 3
Mouse 6 1 491 12 A1.1 Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Rat 6 1 491 6q14 Kcns3 potassium voltage-gated channel
Previous and Unofficial Names
delayed-rectifier K(+) channel alpha subunit 3 | voltage-gated potassium channel subunit Kv9.3 | potassium voltage-gated channel, modifier subfamily S, member 3 | potassium voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
Activator Comments
Kv9.3 / Kv2.1 form ATP-dependent delayed rectifier channels in oxygen-sensitive pulmonary myocytes.
Hypoxia blocks Kv9.3 / Kv2.1 channels [1-5]
Gating Inhibitor Comments
Kv9.3 / Kv2.1 heteromers inactivate in a fast and complete fashion from intermediate closed states but in a slow and incomplete manner from open states [2]
Kv2.1 / Kv9.3 heteromeric channels are inhibited by hypoxia in the voltage range of the PA VSMC EM [1]
Tissue Distribution
Heart, brain, spleen, lung, kidney, artery
Species:  Rat
Technique:  Northern Blot
References:  3,5
General Comments
The human Kv9.3 gene is intronless across the coding region 3'-UTR and all of the analysed 5'-UTR [4]


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1. Hulme JT, Coppock EA, Felipe A, Martens JR, Tamkun MM. (1999) Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Circ. Res., 85 (6): 489-97. [PMID:10488051]

2. Kerschensteiner D, Stocker M. (1999) Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation. Biophys. J., 77 (1): 248-57. [PMID:10388754]

3. Patel AJ, Lazdunski M, Honoré E. (1999) Kv2.1/Kv9.3, an ATP-dependent delayed-rectifier K+ channel in pulmonary artery myocytes. Ann. N. Y. Acad. Sci., 868: 438-41. [PMID:10414317]

4. Shepard AR, Rae JL. (1999) Electrically silent potassium channel subunits from human lens epithelium. Am. J. Physiol., 277 (3 Pt 1): C412-24. [PMID:10484328]

5. Stocker M, Kerschensteiner D. (1998) Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Biochem. Biophys. Res. Commun., 248 (3): 927-34. [PMID:9704029]


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How to cite this page

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv9.3. Last modified on 01/07/2010. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=569.