K<SUB>v</SUB>9.3 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Kv9.3

Target not currently curated in GtoImmuPdb

Target id: 569

Nomenclature: Kv9.3

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 491 2p24 KCNS3 potassium voltage-gated channel modifier subfamily S member 3
Mouse 6 1 491 12 A1.1 Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Rat 6 1 491 6q14 Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3
Previous and Unofficial Names
delayed-rectifier K(+) channel alpha subunit 3 | voltage-gated potassium channel subunit Kv9.3 | potassium voltage-gated channel, modifier subfamily S, member 3 | potassium voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Activator Comments
Kv9.3 / Kv2.1 form ATP-dependent delayed rectifier channels in oxygen-sensitive pulmonary myocytes.
Hypoxia blocks Kv9.3 / Kv2.1 channels [1-5]
Gating Inhibitor Comments
Kv9.3 / Kv2.1 heteromers inactivate in a fast and complete fashion from intermediate closed states but in a slow and incomplete manner from open states [2]
Kv2.1 / Kv9.3 heteromeric channels are inhibited by hypoxia in the voltage range of the PA VSMC EM [1]
Tissue Distribution
Heart, brain, spleen, lung, kidney, artery
Species:  Rat
Technique:  Northern Blot
References:  3,5
General Comments
The human Kv9.3 gene is intronless across the coding region 3'-UTR and all of the analysed 5'-UTR [4]

References

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1. Hulme JT, Coppock EA, Felipe A, Martens JR, Tamkun MM. (1999) Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Circ. Res., 85 (6): 489-97. [PMID:10488051]

2. Kerschensteiner D, Stocker M. (1999) Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation. Biophys. J., 77 (1): 248-57. [PMID:10388754]

3. Patel AJ, Lazdunski M, Honoré E. (1999) Kv2.1/Kv9.3, an ATP-dependent delayed-rectifier K+ channel in pulmonary artery myocytes. Ann. N. Y. Acad. Sci., 868: 438-41. [PMID:10414317]

4. Shepard AR, Rae JL. (1999) Electrically silent potassium channel subunits from human lens epithelium. Am. J. Physiol., 277 (3): C412-24. [PMID:10484328]

5. Stocker M, Kerschensteiner D. (1998) Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Biochem. Biophys. Res. Commun., 248 (3): 927-34. [PMID:9704029]

Contributors

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