Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	1	1017	17q21.2	KCNH4	potassium voltage-gated channel subfamily H member 4
Mouse	6	1	1018	11 D	Kcnh4	potassium voltage-gated channel, subfamily H (eag-related), member 4
Rat	6	1	1017	10q31	Kcnh4	potassium voltage-gated channel subfamily H member 4

Previous and Unofficial Names

BEC2 | Elk1 | brain-specific eag-like channel 2 | ELK channel 1 | ether-a-go-go-like potassium channel 1 | potassium voltage-gated channel, subfamily H (eag-related), member 4 | potassium channel, voltage gated eag related subfamily H, member 4 | potassium voltage-gated channel

Database Links
Alphafold	Q9UQ05 (Hs), Q9R1T9 (Rn)
CATH/Gene3D	2.60.120.10
Ensembl Gene	ENSG00000089558 (Hs), ENSMUSG00000035355 (Mm), ENSRNOG00000018790 (Rn)
Entrez Gene	23415 (Hs), 142984 (Mm), 114032 (Rn)
Human Protein Atlas	ENSG00000089558 (Hs)
KEGG Gene	hsa:23415 (Hs), mmu:142984 (Mm), rno:114032 (Rn)
OMIM	604528 (Hs)
Pharos	Q9UQ05 (Hs)
RefSeq Nucleotide	NM_012285 (Hs), NM_001081194 (Mm), NM_053630 (Rn)
RefSeq Protein	NP_036417 (Hs), NP_001074663 (Mm), NP_446082 (Rn)
UniProtKB	Q9UQ05 (Hs), Q9R1T9 (Rn)
Wikipedia	KCNH4 (Hs)

Ion Selectivity and Conductance
Species:  Rat Macroscopic current rectification:  Ik References:  1

Voltage Dependence
V0.5 (mV)  τ (msec)  Reference  Cell type  Species  Activation  -59.0 38.0 1 CHO cells. Rat Inactivation  - - Deactivation  - 200.0 1 Comments  τ deactivation at -80mV [1]

Gating Inhibitor Comments

Voltage clamp of Kv12.3 heterologously expressed in HEK293 cells demonstrated that external H+ is a gating inhibitor with a pKa of 7.1 and holding voltage -60mV [2].

Channel Blocker Comments

At millimolar concentrations, Ba2+ acts as a pore blocker for Kv12.3 [1]. Kv12.3 is resistant to block by external TEA, 4-AP, E-4031 [1].

Tissue Distribution
Cerebral cortex, occipital pole, fromtal lobe, tenporal lobe, putamen, caudate nucleus, hippocampus. Species:  Human Technique:  Northern blot References:  3
Piriform cortex, olfactory tubercle, cerebral cortex layers II-VI, hippocampus, basal ganglia Species:  Rat Technique:  In situ hybridisation References:  4
Pituitary and clonal somato-mammotroph cells (GH3 / B6 cells) Species:  Rat Technique:  RT-PCR References:  5
Lung, spinal cord, hippocampus, cortex, striatum, pituitary, medulla Species:  Rat Technique:  RT-PCR References:  1
Brain, testes Species:  Rat Technique:  Northern blot References:  1

Functional Assays
Membrane currents recorded from heterologously expressed channels using whole-cell patch clamp Species:  Rat Tissue:  CHO (Chinese Hamster Ovary) cells Response measured:  Remarkably low threshold of activation, may contribute to the maintenance of the resting potential. Activation kinetics not dependent on prepulse potential. References:  1

General Comments
This channel has: GFG (rather than the common GYG) potassium channel signature sequence a PAS domain in the distal part of the cytosolic N-terminus a cNBD domain in the proximal portion of the C-terminus