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Gene and Protein Information ![]() |
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class A G protein-coupled receptor | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 355 | 3p22.1 | CCR8 | C-C motif chemokine receptor 8 | 12,14-15,17-18 |
Mouse | 7 | 353 | 9 F4 | Ccr8 | C-C motif chemokine receptor 8 | 7 |
Rat | 7 | - | 8q32 | Ccr8 | C-C motif chemokine receptor 8 |
Previous and Unofficial Names ![]() |
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ChemR1 [15] | CKR-L1 [18] | TER1 [11-12] | GPR-CY6 |
Database Links ![]() |
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Specialist databases | |
GPCRdb | ccr8_human (Hs), ccr8_mouse (Mm) |
Other databases | |
Alphafold | P51685 (Hs), P56484 (Mm) |
ChEMBL Target | CHEMBL4596 (Hs), CHEMBL1075278 (Mm) |
Ensembl Gene | ENSG00000179934 (Hs), ENSMUSG00000042262 (Mm), ENSRNOG00000026759 (Rn) |
Entrez Gene | 1237 (Hs), 12776 (Mm), 301066 (Rn) |
Human Protein Atlas | ENSG00000179934 (Hs) |
KEGG Gene | hsa:1237 (Hs), mmu:12776 (Mm), rno:301066 (Rn) |
OMIM | 601834 (Hs) |
Pharos | P51685 (Hs) |
RefSeq Nucleotide | NM_005201 (Hs), NM_007720 (Mm), XM_236704 (Rn) |
RefSeq Protein | NP_005192 (Hs), NP_031746 (Mm), XP_236704 (Rn) |
UniProtKB | P51685 (Hs), P56484 (Mm) |
Wikipedia | CCR8 (Hs) |
Natural/Endogenous Ligands ![]() |
CCL1 {Sp: Human} , CCL1 {Sp: Mouse} |
CCL8 {Sp: Mouse} |
Comments: CCL1 is the principal endogenous agonist |
Download all structure-activity data for this target as a CSV file
Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific agonist tables |
Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
CCR8 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. |
Immuno Process Associations | ||||||||||||
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Primary Transduction Mechanisms ![]() |
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Transducer | Effector/Response |
Gi/Go family | Calcium channel |
References: 17 |
Tissue Distribution ![]() |
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Expression Datasets ![]() |
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Functional Assays ![]() |
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Physiological Functions ![]() |
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Physiological Consequences of Altering Gene Expression ![]() |
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Phenotypes, Alleles and Disease Models ![]() |
Mouse data from MGI | ||||||||||||||||||||||||
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1. Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A et al.. (1998) Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol, 28 (2): 582-8. [PMID:9521068]
2. Bernardini G, Spinetti G, Ribatti D, Camarda G, Morbidelli L, Ziche M, Santoni A, Capogrossi MC, Napolitano M. (2000) I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo. Blood, 96 (13): 4039-45. [PMID:11110671]
3. Bishop B, Lloyd CM. (2003) CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease. J Immunol, 170 (9): 4810-7. [PMID:12707363]
4. Chensue SW, Lukacs NW, Yang TY, Shang X, Frait KA, Kunkel SL, Kung T, Wiekowski MT, Hedrick JA, Cook DN et al.. (2001) Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med, 193 (5): 573-84. [PMID:11238588]
5. Dairaghi DJ, Fan RA, McMaster BE, Hanley MR, Schall TJ. (1999) HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem, 274 (31): 21569-74. [PMID:10419462]
6. Freeman CM, Chiu BC, Stolberg VR, Hu J, Zeibecoglou K, Lukacs NW, Lira SA, Kunkel SL, Chensue SW. (2005) CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice. J Immunol, 174 (4): 1962-70. [PMID:15699124]
7. Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G. (1998) Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol, 160 (4): 1975-81. [PMID:9469461]
8. Haskell CA, Horuk R, Liang M, Rosser M, Dunning L, Islam I, Kremer L, Gutiérrez J, Marquez G, Martinez-A C et al.. (2006) Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol, 69 (1): 309-16. [PMID:16221874]
9. Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H. (2002) Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol, 168 (12): 6244-52. [PMID:12055238]
10. Inngjerdingen M, Damaj B, Maghazachi AA. (2001) Expression and regulation of chemokine receptors in human natural killer cells. Blood, 97 (2): 367-75. [PMID:11154210]
11. Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H. (1998) Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection. Biochem Biophys Res Commun, 243 (2): 497-502. [PMID:9480837]
12. Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Santoni A. (1996) Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. J Immunol, 157: 2759-2763. [PMID:8816377]
13. Qu C, Edwards EW, Tacke F, Angeli V, Llodrá J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N et al.. (2004) Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med, 200 (10): 1231-41. [PMID:15534368]
14. Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B. (1997) Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem, 272 (28): 17251-4. [PMID:9211859]
15. Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M. (1996) Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor. Eur J Immunol, 26 (12): 3021-8. [PMID:8977299]
16. Spinetti G, Bernardini G, Camarda G, Mangoni A, Santoni A, Capogrossi MC, Napolitano M. (2003) The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway. J Leukoc Biol, 73: 201-207. [PMID:12525579]
17. Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM. (1997) Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. J Exp Med, 186 (1): 165-70. [PMID:9207005]
18. Zaballos A, Varona R, Gutierrez J, Lind P, Marquez G. (1996) Molecular cloning and RNA expression of two new human chemokine receptor-like genes. Biochem Biophys Res Commun, 227: 846-853. [PMID:8886020]