Top ▲
target has curated data in GtoImmuPdb
Target id: 986
Nomenclature: Peptide transporter 3
Abbreviated Name: PHT2
Systematic Nomenclature: SLC15A3
Gene and Protein Information  |
||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 12 | 581 | 11q12.2 | SLC15A3 | solute carrier family 15 member 3 | |
| Mouse | 12 | 578 | 19 A | Slc15a3 | solute carrier family 15, member 3 | |
| Rat | 12 | 582 | 1q43 | Slc15a3 | solute carrier family 15 member 3 | |
| Previous and Unofficial Names |
| solute carrier family 15 | peptide/histidine transporter PHT2 | PTR3 | solute carrier family 15 member 3 | solute carrier family 15 (oligopeptide transporter), member 3 |
| Database Links |
|
| Specialist databases | |
| Bioparadigms SLC Tables | SLC15A3 (Hs) |
| RESOLUTE | SLC15A3 (Hs) |
| Other databases | |
| Alphafold | Q8IY34 (Hs), Q8BPX9 (Mm), Q924V4 (Rn) |
| Ensembl Gene | ENSG00000110446 (Hs), ENSMUSG00000024737 (Mm), ENSRNOG00000021644 (Rn) |
| Entrez Gene | 51296 (Hs), 65221 (Mm), 246239 (Rn) |
| Human Protein Atlas | ENSG00000110446 (Hs) |
| KEGG Gene | hsa:51296 (Hs), mmu:65221 (Mm), rno:246239 (Rn) |
| OMIM | 610408 (Hs) |
| Pharos | Q8IY34 (Hs) |
| UniProtKB | Q8IY34 (Hs), Q8BPX9 (Mm), Q924V4 (Rn) |
| Wikipedia | SLC15A3 (Hs) |
| Substrates and Reaction Kinetics |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stoichiometry |
|
| PHT2 has not been analyzed systematically with respect to driving force, mode of transport, and substrate specificity. The pH dependence observed for transport of histidine [2] and the model peptides used, i.e., carnosine [2] and histidyl-leucine [2], suggest a similar mode of operation as PEPT1 and PEPT2 proteins. | |
| Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Immunopharmacology Comments |
| SLC15A3 and SLC15A4 are preferentially expressed by cells within the lymphatic system, including dendritic cells. Expression of these two genes is upregulated in response to TLR stimulation [1,3]. There is some experimental evidence which suggests that SLC15A3 plays an important role in regulating TLR4-mediated inflammatory responses [3]. |
| Cell Type Associations | ||||||
|
1. Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I. (2014) Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature, 509 (7499): 240-4. [PMID:24695226]
2. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M. (2001) Cloning of a lymphatic peptide/histidine transporter. Biochem J, 356 (Pt 1): 53-60. [PMID:11336635]
3. Song F, Yi Y, Li C, Hu Y, Wang J, Smith DE, Jiang H. (2018) Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage. Cell Death Dis, 9 (7): 770. [PMID:29991810]
4. Wang Y, Hu Y, Li P, Weng Y, Kamada N, Jiang H, Smith DE. (2018) Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice. Biochem Pharmacol, 148: 163-173. [PMID:29305856]
5. Wang Y, Li P, Song F, Yang X, Weng Y, Ma Z, Wang L, Jiang H. (2019) Substrate Transport Properties of the Human Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells. J Pharm Sci, 108 (10): 3416-3424. [PMID:31254495]
