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ABCC subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins (MRPs). The MRP proteins are found throughout nature and they mediate many important functions. They are known to be involved in ion transport, toxin secretion, and signal transduction [1,5].

Transporters

781
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MRP1 (ABCC1) C Show summary » More detailed page go icon to follow link

MRP2, cMOAT (ABCC2) C Show summary » More detailed page go icon to follow link

MRP3 (ABCC3) C Show summary »


Target Id 781
Systematic nomenclature ABCC3
Common abbreviation MRP3
Previous and unofficial names MOAT-D | Multidrug resistance-associated protein 3 | multi-specific organic anion transporter-D | cMOAT2 | MLP2 | MRP3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | MRP-like protein 2 | multidrug resistance protein 3 | organic anion transporter | canalicular multispecific organic anion transporter 2 | ATP-binding cassette, subfamily C (CFTR/MRP), member 3 | ATP-binding cassette
Genes ABCC3 (Hs), Abcc3 (Mm), Abcc3 (Rn)
Ensembl ID ENSG00000108846 (Hs), ENSMUSG00000020865 (Mm), ENSRNOG00000002948 (Rn)
UniProtKB AC O15438 (Hs), B2RX12 (Mm), O88563 (Rn)
Comment Transports conjugates of glutathione, sulfate or glucuronide [3]

MRP4 (ABCC4) C Show summary » More detailed page go icon to follow link

MRP5 (ABCC5) C Show summary »

MRP6 (ABCC6) C Show summary »

SUR1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 8 / ABCC8) C Show summary » More detailed page go icon to follow link

SUR2 (ABCC9) C Show summary » More detailed page go icon to follow link

MRP7 (ABCC10) Show summary »

MRP8 (ABCC11) C Show summary »

MRP9 (ABCC12) Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.